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@article{777837,
author = {Repko, Martin and Horký, Drahomír and Krbec, Martin and Chaloupka, R. and Brichtová, Eva and Lauschová, Irena and Horký, Drahomír and Krbec, Martin and Chaloupka, R. and Brichtová, Eva and Lauschová, Irena},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s00381-007-0555-7},
keywords = {autonomic nervous system; idiopathic scoliosis; etiology; electron microscopy; morphometry; myelin; concavity},
language = {eng},
issn = {0256-7040},
journal = {Childs nervous system},
title = {The role of the autonomic nervous system in the etiology of idiopathic scoliosis: prospective electron microscopic and morphometric study},
volume = {24},
year = {2008}
}
TY - JOUR
ID - 777837
AU - Repko, Martin - Horký, Drahomír - Krbec, Martin - Chaloupka, R. - Brichtová, Eva - Lauschová, Irena - Horký, Drahomír - Krbec, Martin - Chaloupka, R. - Brichtová, Eva - Lauschová, Irena
PY - 2008
TI - The role of the autonomic nervous system in the etiology of idiopathic scoliosis: prospective electron microscopic and morphometric study
JF - Childs nervous system
VL - 24
IS - 6
SP - 731-734
EP - 731-734
SN - 02567040
KW - autonomic nervous system
KW - idiopathic scoliosis
KW - etiology
KW - electron microscopy
KW - morphometry
KW - myelin
KW - concavity
N2 - The exact etiology of scoliosis is still unknown. The main purpose of this study is to search for the possible causation of scoliosis in the development changes of autonomic nervous structures. In this prospective study, we followed-up the changes in peripheral nerve structures and its discrepancies regarding the concavity and convexity of the scoliotic curve. Materials and methods We evaluated 12 patients with the idiopathic scoliotic deformity and the control group of 3 patients without any scoliotic deformity. The samples from the peripheral nerves of the convexity and concavity of the scoliotic deformity were drawn during the surgical correction by using the transthoracic approach. The samples were examined by the electron microscopic method and morphometric statistical evaluation. Results In samples taken from the scoliotic convexity, 23.71% of myelinized nerve fibers (MNF), 12.21% of unmyelinized nerve fibers (UNF), and 5.0% of Schwann cells (SC) were found by the morphometric measurement. There were 17.36% of MNF, 5.82% of UNF, and 5.27% of SC in samples taken from the concavity and 29.9% of MNF, 19.9% of UNF, and 16.7% of SC in the control nonscoliotic samples. Statistically significant differences between both sides of scoliotic deformity (convexity and concavity) and differences between the scoliotic samples and the nonscoliotic control samples were found. In all scoliotic samples, significant morphologic changes were found, mostly in the myelin sheaths and axon fiber abnormalities compression. Conclusion There are significant morphologic changes in spinal autonomic nervous structures in scoliotic patients. These findings can help us in the search for the etiology of scoliosis.
ER -
REPKO, Martin, Drahomír HORKÝ, Martin KRBEC, R. CHALOUPKA, Eva BRICHTOVÁ a Irena LAUSCHOVÁ. The role of the autonomic nervous system in the etiology of idiopathic scoliosis: prospective electron microscopic and morphometric study. \textit{Childs nervous system}. 2008, roč.~24, č.~6, s.~731-734. ISSN~0256-7040. Dostupné z: https://dx.doi.org/10.1007/s00381-007-0555-7.
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