Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats

PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ. Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats. European Neuropsychopharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2008, vol. 18, Suppl.4, p. S258, 1 pp. ISSN 0924-977X.

Basic information

• Original name: Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats
• Name in Czech: Účinky aripiprazolu na chování a leukocytární fagocytózu v potkaním modelu deprese - olfaktorické bulbektomie
• Authors: PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ.
• Edition: European Neuropsychopharmacology, Amsterdam, The Netherlands, Elsevier Science B.V. 2008, 0924-977X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.661
• Organization unit: Faculty of Medicine
• UT WoS: 000259593800223
• Keywords in English: aripiprazole; olfactory bulbectomy; immunity; behaviour; depression; animal model
• Tags: animal model, aripiprazole, behaviour, Depression, immunity, olfactory bulbectomy
• Tags: International impact

Abstract

Aripiprazole is an atypical antipsychotic, which displays partial agonist activity at the dopamine D2 receptor and is approved also for the treatment of affective disorders. Present study was undertaken to evaluate the applicability of the well-established olfactory bulbectomy (OB) rat model of experimental depression for the assessment of aripiprazole antidepressant effects. Since the affective disorders are often accompanied by the immune system dysfunction [2], the leukocyte phagocytosis representing the cell immune function was measured together with the behavioural changes. Aripiprazole exhibited a significant positive influence on the impaired behavioural and immune changes in the OB rats serving as model of depression. Thus, chronic treatment with this antipsychotic drug can modulate the cell immune function, which may add to its clinical efficacy.

Abstract (in Czech)

Aripiprazol je atypické antipsychotikum s parciální agonistickou aktivitou na dopaminových D2 receptorech, který byl schválen pro léčbu afektivních poruch. Předkládaná studie měla cíl posoudit antidepresivní účinnost aripiprazolu v modelu bilaterální olfaktorické bulbektomie u potkanů. U testované látky jsme v použitém zvířecím modelu prokázali pozitivní vliv jak na chování, tak na buněčnou imunitní funkci - leukocytární fagocytózu. Nelze vyloučit, že modulace funkce imunitního systémů aripiprazolem, může být jedním z mechanismů jeho klinické účinnosti.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.