IZAKOVIČOVÁ HOLLÁ, Lydie, Marcel SCHÜLLER, Dagmar KINDLOVÁ and Vladimír ZNOJIL. Haplotype analysis of interleukine 18 (IL-18) gene in Czech patients with allergic asthma. 2008.
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Basic information
Original name Haplotype analysis of interleukine 18 (IL-18) gene in Czech patients with allergic asthma
Name in Czech Haplotypová analýza genu pro interleukin 18 (IL-18) u českých pacientů s alergickým astmatem
Authors IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Marcel SCHÜLLER (203 Czech Republic), Dagmar KINDLOVÁ (203 Czech Republic) and Vladimír ZNOJIL (203 Czech Republic).
Edition 2008.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30300 3.3 Health sciences
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/08:00024939
Organization unit Faculty of Medicine
Keywords in English haplotype; asthma; polymorphism; interleukin 18; gene; allergic
Tags allergic, asthma, gene, haplotype, interleukin 18, polymorphism
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 16/3/2010 22:40.
Abstract
To test a possible role of IL-18 gene polymorphisms in a Czech population, case-control study including 284 patients with allergic asthma and 312 healthy control subjects was performed. Our results indicate that the three promoter polymorphisms in the IL-18 gene act in a cooperative fashion and suggest that IL-18 haplotypes could play a role in the pathogenesis of allergic asthma in a Czech population.
Abstract (in Czech)
V práci jsme analyzovali možnou úlohu polymorfizmů v genu pro IL-18 v české populaci ve studii kontroly-případy, do níž bylo zařazeno 284 pacientů s alergickým astmatem a 312 zdravých kontrolních osob. Naše výsledky naznačují, že 3 promotorové polymorfizmy v genu pro IL-18 vzájemně spolupůsobí a mohou hrát roli v patogenezi alergického astmatu v české populaci.
Links
GA310/06/0827, research and development projectName: Genetické determinanty pro-/antioxidační rovnováhy v patogeneze respiračních nemocí
Investor: Czech Science Foundation
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