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@article{783358,
author = {Izakovičová Hollá, Lydie and Mrázek, František and Petřek, Martin},
article_location = {Anglie},
article_number = {1},
keywords = {Allergy; CCR2; gene; MCP-1; polymorphism},
language = {eng},
issn = {1744-3121},
journal = {Int J Immunogenet},
note = {2008, Nov 25. [Epub ahead of print]},
title = {MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders},
volume = {36},
year = {2009}
}
TY - JOUR
ID - 783358
AU - Izakovičová Hollá, Lydie - Mrázek, František - Petřek, Martin
PY - 2009
TI - MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders
JF - Int J Immunogenet
VL - 36
IS - 1
SP - 69-72
EP - 69-72
PB - Blackwell
SN - 17443121
N1 - 2008, Nov 25. [Epub ahead of print]
KW - Allergy
KW - CCR2
KW - gene
KW - MCP-1
KW - polymorphism
N2 - Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analyzed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n=306) and allergic patients (n=332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.
ER -
IZAKOVIČOVÁ HOLLÁ, Lydie, František MRÁZEK and Martin PETŘEK. MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders. \textit{Int J Immunogenet}. Anglie: Blackwell, 2009, vol.~36, No~1, p.~69-72. ISSN~1744-3121.
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