Detailed Information on Publication Record
2008
The effects of TGFb proteins on osteoclast differentiation
VAŇHARA, Petr, Eva LINCOVÁ, Karel SOUČEK and Jan ŠMARDABasic information
Original name
The effects of TGFb proteins on osteoclast differentiation
Name in Czech
Vliv proteinů rodiny TGFb na diferenciaci osteoklastů
Authors
VAŇHARA, Petr (203 Czech Republic), Eva LINCOVÁ (203 Czech Republic), Karel SOUČEK (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor)
Edition
1. vyd. Hersonissos, Greece, Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine, p. 28-29, 2008
Publisher
International Journal of Molecular Medicine Vol. 22, supplement 1, 2008
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
Genetics and molecular biology
Country of publisher
Greece
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.880
RIV identification code
RIV/00216224:14310/08:00024950
Organization unit
Faculty of Science
ISSN
Keywords in English
osteoclasts; TGF beta; prostate cancer
Tags
Tags
International impact, Reviewed
Změněno: 9/7/2010 10:47, prof. RNDr. Jan Šmarda, CSc.
V originále
Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts.
In Czech
Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes, such as.In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts.
Links
| GA301/06/0036, research and development project |
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| GD204/08/H054, research and development project |
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| MSM0021622415, plan (intention) |
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