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@inbook{789394,
author = {Damborský, Jiří and Chaloupková, Radka and Pavlová, Martina and Chovancová, Eva and Brezovský, Jan},
address = {Heidelberg},
booktitle = {Handbook of Hydrocarbon and Lipid Microbiology},
edition = {1.},
keywords = {QSAR; haloalkan dehalogenases},
language = {eng},
location = {Heidelberg},
isbn = {978-3-540-77584-3},
pages = {1081-1098},
publisher = {Springer},
title = {Structure-Function Relationships and Engineering of Haloalkane Dehalogenases},
url = {http://www.springerlink.com/content/n267721405777j1m/},
year = {2008}
}
TY - CHAP
ID - 789394
AU - Damborský, Jiří - Chaloupková, Radka - Pavlová, Martina - Chovancová, Eva - Brezovský, Jan
PY - 2008
TI - Structure-Function Relationships and Engineering of Haloalkane Dehalogenases
VL - Handbooks, 1
PB - Springer
CY - Heidelberg
SN - 9783540775843
KW - QSAR
KW - haloalkan dehalogenases
UR - http://www.springerlink.com/content/n267721405777j1m/
N2 - The structure–function relationships for haloalkane dehalogenases, representing one of the best characterized families of enzymes involved in degradation of halogenated compounds is described. A substantial amount of mechanistic and structural information is currently available on haloalkane dehalogenases, providing good theoretical framework for their modification by protein engineering. Examples of constructed mutants include variants with modified: (1) activity, (2) thermostability, (3) substrate specificity and (4) enantioselectivity. Some variants carried mutations in the tunnels, connecting the buried active site with surrounding solvent, rather in the active site itself. Mutagenesis in the residues lining the protein tunnels represents a new paradigm in protein engineering.
ER -
DAMBORSKÝ, Jiří, Radka CHALOUPKOVÁ, Martina PAVLOVÁ, Eva CHOVANCOVÁ a Jan BREZOVSKÝ. Structure-Function Relationships and Engineering of Haloalkane Dehalogenases. In \textit{Handbook of Hydrocarbon and Lipid Microbiology}. 1. vyd. Heidelberg: Springer, 2008, s.~1081-1098. Handbooks, 1. ISBN~978-3-540-77584-3.
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