Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis

FLEISCHMANNOVÁ, Jana, Herve LESOT, Eva MATALOVÁ, Kirsti WITTER, Petra MATULOVÁ a Ivan MÍŠEK. Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis. The International journal of developmental biology. Spain: University Of The Basque Country Press, 2006, Neuveden, č. 50, s. 481-489, 8 s. ISSN 0214-6282.

Základní údaje

• Originální název: Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis
• Název česky: Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis
• Autoři: FLEISCHMANNOVÁ, Jana (203 Česká republika), Herve LESOT (250 Francie), Eva MATALOVÁ (203 Česká republika), Kirsti WITTER (276 Německo), Petra MATULOVÁ (203 Česká republika, garant) a Ivan MÍŠEK (203 Česká republika).
• Vydání: The International journal of developmental biology, Spain, University Of The Basque Country Press, 2006, 0214-6282.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 10600 1.6 Biological sciences
• Stát vydavatele: Španělsko
• Utajení: není předmětem státního či obchodního tajemství
• Impakt faktor: Impact factor: 3.577
• Organizační jednotka: Přírodovědecká fakulta
• UT WoS: 000237787100006
• Klíčová slova anglicky: tooth development; morphogenesis; Microtus; dentition; 3D reconstruction
• Štítky: 3D reconstruction, dentition, Microtus, morphogenesis, tooth development
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Proliferation and apoptosis play crucial roles in the development of multicellular organisms. Their precise balance is necessary for tissue homeostasis throughout life. The developing dentition is a suitable model to study proliferation and apoptosis during embryogenesis, but the corresponding studies have been carried out principally in the mouse. The present aimed to examine proliferation and apoptosis in the vole (Microtus sp., Rodentia) during the early morphogenesis of the first upper molar and compare it to what is known from the mouse. To this end, apoptosis and proliferation were investigated using histology and computer-aided 3D reconstruction. Mitoses accumulated predominantly in the developing cervical loop. Apoptosis during early odontogenesis showed highly specific spatio-temporal patterns in the dental epithelium. Apoptotic bodies were localised in non-dividing cell populations. They accumulated in the same places as described in the mouse: antemolar vestiges (ED 12.5-15.5), enamel knot (ED 14.5-15.5), stalk and palatally along the whole first molar tooth germ longitudinal axis (ED 15-15.5). Early tooth development in the field vole, including the distribution of apoptosis and mitosis, is very similar to that reported in the mouse, with the exception of the antemolar region. The microtine antemolar vestige is preserved longer than the murine one. It is conceivable that additional distinct differences in morphogenetic processes appear later in tooth development.

Anotace česky

Proliferation and apoptosis play crucial roles in the development of multicellular organisms. Their precise balance is necessary for tissue homeostasis throughout life. The developing dentition is a suitable model to study proliferation and apoptosis during embryogenesis, but the corresponding studies have been carried out principally in the mouse. The present aimed to examine proliferation and apoptosis in the vole (Microtus sp., Rodentia) during the early morphogenesis of the first upper molar and compare it to what is known from the mouse. To this end, apoptosis and proliferation were investigated using histology and computer-aided 3D reconstruction. Mitoses accumulated predominantly in the developing cervical loop. Apoptosis during early odontogenesis showed highly specific spatio-temporal patterns in the dental epithelium. Apoptotic bodies were localised in non-dividing cell populations. They accumulated in the same places as described in the mouse: antemolar vestiges (ED 12.5-15.5), enamel knot (ED 14.5-15.5), stalk and palatally along the whole first molar tooth germ longitudinal axis (ED 15-15.5). Early tooth development in the field vole, including the distribution of apoptosis and mitosis, is very similar to that reported in the mouse, with the exception of the antemolar region. The microtine antemolar vestige is preserved longer than the murine one. It is conceivable that additional distinct differences in morphogenetic processes appear later in tooth development.