Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis

FLEISCHMANNOVÁ, Jana; Herve LESOT; Eva MATALOVÁ; Kirsti WITTER; Petra MATULOVÁ a Ivan MÍŠEK. Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis. The International journal of developmental biology. Spain: University Of The Basque Country Press, 2006, Neuveden, č. 50, s. 481-489, 8 s. ISSN 0214-6282.

Základní údaje

Originální název

Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis

Název česky

Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis

Autoři

FLEISCHMANNOVÁ, Jana; Herve LESOT; Eva MATALOVÁ; Kirsti WITTER; Petra MATULOVÁ a Ivan MÍŠEK

Vydání

The International journal of developmental biology, Spain, University Of The Basque Country Press, 2006, 0214-6282

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Španělsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.577

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000237787100006

Klíčová slova anglicky

tooth development; morphogenesis; Microtus; dentition; 3D reconstruction

Štítky

3D reconstruction, dentition, Microtus, morphogenesis, tooth development

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Proliferation and apoptosis play crucial roles in the development of multicellular organisms. Their precise balance is necessary for tissue homeostasis throughout life. The developing dentition is a suitable model to study proliferation and apoptosis during embryogenesis, but the corresponding studies have been carried out principally in the mouse. The present aimed to examine proliferation and apoptosis in the vole (Microtus sp., Rodentia) during the early morphogenesis of the first upper molar and compare it to what is known from the mouse. To this end, apoptosis and proliferation were investigated using histology and computer-aided 3D reconstruction. Mitoses accumulated predominantly in the developing cervical loop. Apoptosis during early odontogenesis showed highly specific spatio-temporal patterns in the dental epithelium. Apoptotic bodies were localised in non-dividing cell populations. They accumulated in the same places as described in the mouse: antemolar vestiges (ED 12.5-15.5), enamel knot (ED 14.5-15.5), stalk and palatally along the whole first molar tooth germ longitudinal axis (ED 15-15.5). Early tooth development in the field vole, including the distribution of apoptosis and mitosis, is very similar to that reported in the mouse, with the exception of the antemolar region. The microtine antemolar vestige is preserved longer than the murine one. It is conceivable that additional distinct differences in morphogenetic processes appear later in tooth development.

Česky

Proliferation and apoptosis play crucial roles in the development of multicellular organisms. Their precise balance is necessary for tissue homeostasis throughout life. The developing dentition is a suitable model to study proliferation and apoptosis during embryogenesis, but the corresponding studies have been carried out principally in the mouse. The present aimed to examine proliferation and apoptosis in the vole (Microtus sp., Rodentia) during the early morphogenesis of the first upper molar and compare it to what is known from the mouse. To this end, apoptosis and proliferation were investigated using histology and computer-aided 3D reconstruction. Mitoses accumulated predominantly in the developing cervical loop. Apoptosis during early odontogenesis showed highly specific spatio-temporal patterns in the dental epithelium. Apoptotic bodies were localised in non-dividing cell populations. They accumulated in the same places as described in the mouse: antemolar vestiges (ED 12.5-15.5), enamel knot (ED 14.5-15.5), stalk and palatally along the whole first molar tooth germ longitudinal axis (ED 15-15.5). Early tooth development in the field vole, including the distribution of apoptosis and mitosis, is very similar to that reported in the mouse, with the exception of the antemolar region. The microtine antemolar vestige is preserved longer than the murine one. It is conceivable that additional distinct differences in morphogenetic processes appear later in tooth development.