Impact of behavioural sensitization and estrogen levels on i.v.
self-adminitration of methamphetamine in rats

D 2008

Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats

KUČEROVÁ, Jana; Dagmar VRŠKOVÁ a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats

Název česky

Vliv behaviorální sensitizace a hladiny estrogenů na "i.v. self-adminitration" metamfetaminu u potkana

Autoři

KUČEROVÁ, Jana; Dagmar VRŠKOVÁ a Alexandra ŠULCOVÁ

Vydání

Hradec Králové, New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students, od s. 20-21, 2 s. 2008

Nakladatel

Charles University in Prague, faculty of Medicine in Hradec Kralové

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

ISBN

978-80-254-3384-3

UT WoS

000259593801380

Klíčová slova anglicky

methamphetamine; self-administration; behavioral sensitization; gender differences; rats

Štítky

behavioral sensitization, gender differences, methamphetamine, rats, self-administration

Příznaky

Mezinárodní význam

Změněno: 27. 1. 2009 11:11, doc. PharmDr. Jana Rudá, Ph.D.

Anotace

ORIG CZ

V originále

All the animals experienced previously with effects of MET in the phase of pretreatment showed the lower self-administered intake of MET. This might indicate that MET produced more profound rewarding effects in rats previously sensitized to the drug. The female groups in estrus-like conditions self-administered higher doses of MET than male groups with the same treatment however the females in anestrus self-administererd even lower doses than males. This indicates certain enhancing effect of estrogens on MET addiction in laboratory rodent model which is in accordance with other findings from animal and human studies.

Česky

V sadě experimentů bylo prokázáno, že samci i samice ve fázi estru sensitizovaní premedikací MET přijímají vysoce signifikantně nižší dávku MET než nesensitizované skupiny zvířat. U všech sensitizovaných zvířat bylo ve srovnání s nesenzitizovanými jedinci zaznamenáno snížení (p<0.05) příjmu MET, které nebylo statisticky průkazné pouze u kastrovaných samic.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

KUČEROVÁ, Jana; Dagmar VRŠKOVÁ a Alexandra ŠULCOVÁ. Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats. In New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students. Hradec Králové: Charles University in Prague, faculty of Medicine in Hradec Kralové, 2008, s. 20-21. ISBN 978-80-254-3384-3.

@inproceedings{797074,
   author = {Kučerová, Jana and Vršková, Dagmar and Šulcová, Alexandra},
   address = {Hradec Králové},
   booktitle = {New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students},
   keywords = {methamphetamine; self-administration; behavioral sensitization; gender differences; rats},
   language = {eng},
   location = {Hradec Králové},
   isbn = {978-80-254-3384-3},
   pages = {20-21},
   publisher = {Charles University in Prague, faculty of Medicine in Hradec Kralové},
   title = {Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats},
   year = {2008}
}

TY  - CONF
ID  - 797074
AU  - Kučerová, Jana - Vršková, Dagmar - Šulcová, Alexandra
PY  - 2008
TI  - Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats
PB  - Charles University in Prague, faculty of Medicine in Hradec Kralové
CY  - Hradec Králové
SN  - 9788025433843
KW  - methamphetamine
KW  - self-administration
KW  - behavioral sensitization
KW  - gender differences
KW  - rats
N2  - All the animals experienced previously with effects of MET in the phase of pretreatment showed the lower self-administered intake of MET. This might indicate that MET produced more profound rewarding effects in rats previously sensitized to the drug. The female groups in estrus-like conditions self-administered higher doses of MET than male groups with the same treatment however the females in anestrus self-administererd even lower doses than males. This indicates certain enhancing effect of estrogens on MET addiction in laboratory rodent model which is in accordance with other findings from animal and human studies.
ER  -

KUČEROVÁ, Jana; Dagmar VRŠKOVÁ a Alexandra ŠULCOVÁ. Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats. In \textit{New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students}. Hradec Králové: Charles University in Prague, faculty of Medicine in Hradec Kralové, 2008, s.~20-21. ISBN~978-80-254-3384-3.

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