2008
Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus)
SEIFERTOVÁ, Mária; Martina VYSKOČILOVÁ a Andrea VETEŠNÍKOVÁ ŠIMKOVÁZákladní údaje
Originální název
Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus)
Vydání
The Fisheries Society of the British Isles, Annual International Symposium: Parasites as agents of selection in fish: from genes to ecosystems, Cardiff University, Cardiff UK, 2008
Další údaje
Jazyk
angličtina
Typ výsledku
Prezentace na konferencích
Obor
10600 1.6 Biological sciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14310/08:00042180
Organizační jednotka
Přírodovědecká fakulta
Klíčová slova anglicky
MHC; parasite; fish
Příznaky
Mezinárodní význam
Změněno: 28. 4. 2011 14:41, prof. RNDr. Andrea Vetešníková Šimková, PhD.
Anotace
V originále
The polymorphism of major histocompatibility complex (MHC) genes was investigated in relation to parasitism in several populations of chub (Leuciscus cephalus) from different European rivers. The MHC genes are the most polymorphic loci known for vertebrates, whereas tree possible hypotheses of parasite-mediated selection driving an extensive MHC diversity (i.e. overdominance hypothesis, frequency dependent selection hypothesis and hypothesis of optimal number of MHC alleles) have been proposed. Hence, these genes are convenient model for elucidating the host-parasite relationships. It has been predicted that the populations with more genetic variability of MHC will have more diverse array of parasites. The antigens derived from parasites (possible important selective agents) interact with peptide binding region of MHC II molecules, on that account the present study was focused on genetic variability of the exon 2 (DAB1 and DAB3 genes), which encodes the beta 1 domain of the peptide binding region. Considering that the selectively neutral processes (genetic drift) should also contribute to MHC polymorphism, 20 microsatellite loci were analyzed as a neutral marker. The observed metazoan parasite diversity and similarity among chub populations based on the parasite data using qualitative Jaccard index and quantitative Morisita index were compared with genetic diversity of exon 2, microsatellites and geographic distances among fish populations. This study was funded by the by Research Project of the Masaryk University, Brno, Project No.: 0021 622 416 and by the Grant Agency of the Czech Republic, Project No. 524/07/0188.
Návaznosti
| GA524/07/0188, projekt VaV |
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| LC522, projekt VaV |
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| MSM0021622416, záměr |
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