2008
The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
ZENDULKA, Ondřej; Lucia ZAHRADNÍKOVÁ; Jan JUŘICA a Jiří TOTUŠEKZákladní údaje
Originální název
The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
Název česky
Vliv trans-resveratrolu a kvercetinu na aktivitu CYP1A2 u potkana
Název anglicky
The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
Autoři
Vydání
Czech Journal of Food Science, 2008, 1212-1800
Další údaje
Jazyk
čeština
Typ výsledku
Článek v odborném periodiku
Obor
30104 Pharmacology and pharmacy
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 0.472
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/08:00025115
Organizační jednotka
Lékařská fakulta
UT WoS
Klíčová slova anglicky
cytochrome P450; trans-revseratrol; quercetin; perfused rat liver
Změněno: 26. 6. 2009 10:29, RNDr. Jiří Totušek, CSc.
V originále
Polyphenolic compounds are widely distributed among plants and are present also in wine grapes and wine. We determined the influence of polyphenols (trans-resveratrol, quercetin) and sex on the activity of cytochrome P450 in rats. Cytochrome P450 (CYP450) is one of the most important enzymatic systems of biotransformation. Its activity is influenced by many endo- as well as exogenous factors. In our experiment we studied on the model of perfused rat liver the activity of 1A2 isoenzyme, which is being linked with the activation of promutagenes and procarcinogenes. Our results confirmed different metabolic acivity between males and females. Female rats metabolized faster through CYP1A2. Trans-resveratrol didn't influence the activity of CYP1A2, but it enhanced intersexual differences. Based on our results we suggest, that quercetin is an inhibitor of CYP1A2 isoenzyme.
Anglicky
Polyphenolic compounds are widely distributed among plants and are present also in wine grapes and wine. We determined the influence of polyphenols (trans-resveratrol, quercetin) and sex on the activity of cytochrome P450 in rats. Cytochrome P450 (CYP450) is one of the most important enzymatic systems of biotransformation. Its activity is influenced by many endo- as well as exogenous factors. In our experiment we studied on the model of perfused rat liver the activity of 1A2 isoenzyme, which is being linked with the activation of promutagenes and procarcinogenes. Our results confirmed different metabolic acivity between males and females. Female rats metabolized faster through CYP1A2. Trans-resveratrol didn't influence the activity of CYP1A2, but it enhanced intersexual differences. Based on our results we suggest, that quercetin is an inhibitor of CYP1A2 isoenzyme.
Návaznosti
| GA525/06/1757, projekt VaV |
| ||
| MSM0021622404, záměr |
|