Detailed Information on Publication Record
2008
The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
ZENDULKA, Ondřej, Lucia ZAHRADNÍKOVÁ, Jan JUŘICA and Jiří TOTUŠEKBasic information
Original name
The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
Name in Czech
Vliv trans-resveratrolu a kvercetinu na aktivitu CYP1A2 u potkana
Name (in English)
The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
Authors
ZENDULKA, Ondřej (203 Czech Republic, guarantor), Lucia ZAHRADNÍKOVÁ (703 Slovakia), Jan JUŘICA (203 Czech Republic) and Jiří TOTUŠEK (203 Czech Republic)
Edition
Czech Journal of Food Science, 2008, 1212-1800
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.472
RIV identification code
RIV/00216224:14110/08:00025115
Organization unit
Faculty of Medicine
UT WoS
000266082000011
Keywords in English
cytochrome P450; trans-revseratrol; quercetin; perfused rat liver
Změněno: 26/6/2009 10:29, RNDr. Jiří Totušek, CSc.
V originále
Polyphenolic compounds are widely distributed among plants and are present also in wine grapes and wine. We determined the influence of polyphenols (trans-resveratrol, quercetin) and sex on the activity of cytochrome P450 in rats. Cytochrome P450 (CYP450) is one of the most important enzymatic systems of biotransformation. Its activity is influenced by many endo- as well as exogenous factors. In our experiment we studied on the model of perfused rat liver the activity of 1A2 isoenzyme, which is being linked with the activation of promutagenes and procarcinogenes. Our results confirmed different metabolic acivity between males and females. Female rats metabolized faster through CYP1A2. Trans-resveratrol didn't influence the activity of CYP1A2, but it enhanced intersexual differences. Based on our results we suggest, that quercetin is an inhibitor of CYP1A2 isoenzyme.
In English
Polyphenolic compounds are widely distributed among plants and are present also in wine grapes and wine. We determined the influence of polyphenols (trans-resveratrol, quercetin) and sex on the activity of cytochrome P450 in rats. Cytochrome P450 (CYP450) is one of the most important enzymatic systems of biotransformation. Its activity is influenced by many endo- as well as exogenous factors. In our experiment we studied on the model of perfused rat liver the activity of 1A2 isoenzyme, which is being linked with the activation of promutagenes and procarcinogenes. Our results confirmed different metabolic acivity between males and females. Female rats metabolized faster through CYP1A2. Trans-resveratrol didn't influence the activity of CYP1A2, but it enhanced intersexual differences. Based on our results we suggest, that quercetin is an inhibitor of CYP1A2 isoenzyme.
Links
| GA525/06/1757, research and development project |
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| MSM0021622404, plan (intention) |
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