Preparation and cis-to-trans transformation study of
square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins
derived from 6-benzylaminopurine (L-n) by view of NMR
spectroscopy and X-ray crystallography

J 2008

Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography

SZÜČOVÁ, L.; Z. TRÁVNÍČEK; I. POPA a Jaromír MAREK

Základní údaje

Originální název

Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography

Název česky

Příprava a cis-trans transformace čtvercově-planárních platnatých komplexů s benzylaminopurinovými cytokininy očima NMR spektroskopie a RTG strukturní analýzy

Autoři

SZÜČOVÁ, L. (203 Česká republika); Z. TRÁVNÍČEK (203 Česká republika); I. POPA (498 Moldavsko) a Jaromír MAREK (203 Česká republika, garant)

Vydání

Polyhedron, Velká Británie, PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, 2008, 0277-5387

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.801

Kód RIV

RIV/00216224:14310/08:00027229

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000258616400029

Klíčová slova anglicky

Pt(II) complexes; cytokinins; NMR spectroscopy; X-ray structures; in vitro cytotoxicity

Štítky

cytokinins, in vitro cytotoxicity, NMR Spectroscopy, Pt(II) complexes, x-ray structures

Příznaky

Recenzováno

Změněno: 25. 6. 2009 13:05, doc. RNDr. Jaromír Marek, Ph.D.

Anotace

ORIG CZ

V originále

Mononuclear, square-planar platinum(II) complexes involving derivatives of aromatic cytokinins as the ligands, and having the general formula cis-[Pt(L-n)(2)Cl-2] (1-3) and trans-[Pt(L-n)(2)Cl-2] (4-6), where n = 13, L-1 = 2-chloro-6-(benzylamino)-9-isopropylpurine, L-2 = 2-chloro-6-[(4-methoxybenzyl)amino]-9-isopropylpurine and L-3 = 2-chloro-6-[(2-methoxybenzyl)-amino]-9-isopropylpurine, have been synthesized and characterized by elemental analysis, MALDI-TOF mass, FT IR, H-1, C-13, N-15 and Pt-195 NMR spectral measurements. Dynamic cis-to-trans isomerization process of complex 1 in N,N'-dimethylformamide (DMF) has been investigated by means of multinuclear NMR spectroscopy. The solid-state structures of 1, 4 center dot (DMF)(2), and 5 have been determined by single crystal X-ray analysis. X-ray structures revealed that the heterocyclic ligands are coordinated to platinum via nitrogen atom N(7) in all the complexes studied. In vitro cytotoxicity of the prepared complexes against MCF7, G361, K562, and HOS has been evaluated. Owing to low solubility of the complexes in water, the cytotoxicity has been only tested up to 5 mu M concentration. Unfortunately, all complexes have been found to be non-cytotoxic in the accessible concentration range.

Česky

V práci byly studovány čtvercově planární platnaté komplexy s aromatickými cytokininy jako ligandy metodami MALDI, FTR a multijadernou NMR. U vybraných - krystalizovatelných - komplexů byly určeny i jejich 3D krystalové struktury.

Návaznosti

MSM0021622410, záměr

Název: Fyzikální a chemické vlastnosti pokročilých materiálů a struktur

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Fyzikální a chemické vlastnosti pokročilých materiálů a struktur

Citovat

SZÜČOVÁ, L.; Z. TRÁVNÍČEK; I. POPA a Jaromír MAREK. Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography. Polyhedron. Velká Británie: PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, 2008, roč. 27, č. 12, s. 2710-2720. ISSN 0277-5387.

@article{806884,
   author = {Szüčová, L. and Trávníček, Z. and Popa, I. and Marek, Jaromír},
   article_location = {Velká Británie},
   article_number = {12},
   keywords = {Pt(II) complexes; cytokinins; NMR spectroscopy; X-ray structures; in vitro cytotoxicity},
   language = {eng},
   issn = {0277-5387},
   journal = {Polyhedron},
   title = {Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography},
   volume = {27},
   year = {2008}
}

TY  - JOUR
ID  - 806884
AU  - Szüčová, L. - Trávníček, Z. - Popa, I. - Marek, Jaromír
PY  - 2008
TI  - Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography
JF  - Polyhedron
VL  - 27
IS  - 12
SP  - 2710-2720
EP  - 2710-2720
PB  - PERGAMON-ELSEVIER SCIENCE LTD, OXFORD
SN  - 02775387
KW  - Pt(II) complexes
KW  - cytokinins
KW  - NMR spectroscopy
KW  - X-ray structures
KW  - in vitro cytotoxicity
N2  - Mononuclear, square-planar platinum(II) complexes involving derivatives of aromatic cytokinins as the ligands, and having the general formula cis-[Pt(L-n)(2)Cl-2] (1-3) and trans-[Pt(L-n)(2)Cl-2] (4-6), where n = 13, L-1 = 2-chloro-6-(benzylamino)-9-isopropylpurine, L-2 = 2-chloro-6-[(4-methoxybenzyl)amino]-9-isopropylpurine and L-3 = 2-chloro-6-[(2-methoxybenzyl)-amino]-9-isopropylpurine, have been synthesized and characterized by elemental analysis, MALDI-TOF mass, FT IR, H-1, C-13, N-15 and Pt-195 NMR spectral measurements. Dynamic cis-to-trans isomerization process of complex 1 in N,N'-dimethylformamide (DMF) has been investigated by means of multinuclear NMR spectroscopy. The solid-state structures of 1, 4 center dot (DMF)(2), and 5 have been determined by single crystal X-ray analysis. X-ray structures revealed that the heterocyclic ligands are coordinated to platinum via nitrogen atom N(7) in all the complexes studied. In vitro cytotoxicity of the prepared complexes against MCF7, G361, K562, and HOS has been evaluated. Owing to low solubility of the complexes in water, the cytotoxicity has been only tested up to 5 mu M concentration. Unfortunately, all complexes have been found to be non-cytotoxic in the accessible concentration range.
ER  -

SZÜČOVÁ, L.; Z. TRÁVNÍČEK; I. POPA a Jaromír MAREK. Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography. \textit{Polyhedron}. Velká Británie: PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, 2008, roč.~27, č.~12, s.~2710-2720. ISSN~0277-5387.

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