Morphology of fronto-temporal Regions and Word Generation in
First-episode Schizophrenia

J 2008

Morphology of fronto-temporal Regions and Word Generation in First-episode Schizophrenia

KAŠPÁREK, Tomáš, Hana KUČEROVÁ, Radovan PŘIKRYL, Eva ČEŠKOVÁ, Michal MIKL et. al.

Základní údaje

Originální název

Morphology of fronto-temporal Regions and Word Generation in First-episode Schizophrenia

Název česky

Morfologie fronto-temporální oblasti a proces mluvy při první epizodě schizofrenie

Autoři

KAŠPÁREK, Tomáš, Hana KUČEROVÁ, Radovan PŘIKRYL, Eva ČEŠKOVÁ, Michal MIKL a Petr KRUPA

Vydání

Activitas Nervosa Superior, Praha, Neuroscientia o.s. 2008, 1802-9698

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

voxel based morphometry; schizophrenia; FT dysfunction; verbal fluency task

Štítky

FT dysfunction, schizophrenia, verbal fluency task, voxel based morphometry

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 1. 2013 11:28, prof. MUDr. Tomáš Kašpárek, Ph.D.

Anotace

ORIG CZ

V originále

Fronto temporal (FT) dysfunction is a characteristic feature of schizophrenia. We tried to find features of brain morphology that are connected with the solving of Verbal Fluency Task (VFT). We hypothesized that verbal fluency results correlate positively with gray and white matter volume in fronto temporal areas. 25 first episode schizophrenia men were tested using Correlations between VFT score and brain morphology were performed using General linear mode - regression analysis. There was a significant positive correlation of regional gray matter and VFT score in the posterior part of superior temporal gyrus, on the borders with middle temporal gyrus and inferior parietal lobule. As for the regional white matter volume there was one significant cluster in the depth of the inferior frontal gyrus, pars triangularis. The ability to neerate context appropriate words is not only the result of abnormal FT co-operation or ability to "hire" prefrontal activity when necessary, but also stems from the condition of relevant neuronal networks.

Česky

Fronto temporální (FT) porucha je u schizofrenie charakteristická. Hledali jsme, jaké je spojení mezi morfologií mozku a plynulou řečí. (VFT).Předpokládali jsme, že to, jaký je výsledek plynulé řeči nutně souvisí s objemem šedé a bílé hmoty ve frontotemporální oblasti. Testovali jsme 25 osob s první episodou schizofrenie použitím VFT.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

KAŠPÁREK, Tomáš, Hana KUČEROVÁ, Radovan PŘIKRYL, Eva ČEŠKOVÁ, Michal MIKL a Petr KRUPA. Morphology of fronto-temporal Regions and Word Generation in First-episode Schizophrenia. Activitas Nervosa Superior. Praha: Neuroscientia o.s., 2008, roč. 50, č. 4, s. 88-90. ISSN 1802-9698.

@article{806886,
   author = {Kašpárek, Tomáš and Kučerová, Hana and Přikryl, Radovan and Češková, Eva and Mikl, Michal and Krupa, Petr},
   article_location = {Praha},
   article_number = {4},
   keywords = {voxel based morphometry; schizophrenia; FT dysfunction; verbal fluency task},
   language = {eng},
   issn = {1802-9698},
   journal = {Activitas Nervosa Superior},
   title = {Morphology of fronto-temporal Regions and Word Generation in First-episode Schizophrenia},
   volume = {50},
   year = {2008}
}

TY  - JOUR
ID  - 806886
AU  - Kašpárek, Tomáš - Kučerová, Hana - Přikryl, Radovan - Češková, Eva - Mikl, Michal - Krupa, Petr
PY  - 2008
TI  - Morphology of fronto-temporal Regions and Word Generation in First-episode Schizophrenia
JF  - Activitas Nervosa Superior
VL  - 50
IS  - 4
SP  - 88-90
EP  - 88-90
PB  - Neuroscientia o.s.
SN  - 18029698
KW  - voxel based morphometry
KW  - schizophrenia
KW  - FT dysfunction
KW  - verbal fluency task
N2  - Fronto temporal (FT) dysfunction is a characteristic feature of schizophrenia. We tried to find features of brain morphology that are connected with the solving of Verbal Fluency Task (VFT). We hypothesized that verbal fluency results correlate positively with gray and white matter volume in fronto temporal areas. 25 first episode schizophrenia men were tested using Correlations between VFT score and brain morphology were performed using General linear mode - regression analysis. There was a significant positive correlation of regional gray matter and VFT score in the posterior part of superior temporal gyrus, on the borders with middle temporal gyrus and inferior parietal lobule. As for the regional white matter volume there was one significant cluster in the depth of the inferior frontal gyrus, pars triangularis. The ability to neerate context appropriate words is not only the result of abnormal FT co-operation or ability to "hire" prefrontal activity when necessary, but also stems from the condition of relevant neuronal networks.
ER  -

KAŠPÁREK, Tomáš, Hana KUČEROVÁ, Radovan PŘIKRYL, Eva ČEŠKOVÁ, Michal MIKL a Petr KRUPA. Morphology of fronto-temporal Regions and Word Generation in First-episode Schizophrenia. \textit{Activitas Nervosa Superior}. Praha: Neuroscientia o.s., 2008, roč.~50, č.~4, s.~88-90. ISSN~1802-9698.

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