KUNICKÁ, Zuzana, Igor MUCHA and Jiří FAJKUS. Telomerase Activity in Head and Neck Cancer. Anticancer Research. Greece: INT INST ANTICANCER RESEARCH, 2008, vol. 28, 5B, p. 3125-3129. ISSN 0250-7005.
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Basic information
Original name Telomerase Activity in Head and Neck Cancer
Name in Czech Aktivita telomerázy v nádorech hlavy a krku
Authors KUNICKÁ, Zuzana (203 Czech Republic), Igor MUCHA (203 Czech Republic) and Jiří FAJKUS (203 Czech Republic, guarantor).
Edition Anticancer Research, Greece, INT INST ANTICANCER RESEARCH, 2008, 0250-7005.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Greece
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.390
RIV identification code RIV/00216224:14310/08:00024399
Organization unit Faculty of Science
UT WoS 000260555100046
Keywords in English Telomerase activity; head and neck cancer; real-time TRAP; prognosis; marker
Tags head and neck cancer, marker, prognosis, real-time TRAP, telomerase activity
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Jiří Fajkus, CSc., učo 28574. Changed: 26/6/2009 10:46.
Abstract
Telomerase activity was determined using quantitative TRAP method in 58 patients with head and neck cancer. Tumours were positive in 88%. Value of telomerase activity was compared with standard histopatological parametres (T stage, N stage, grade). Measurement ot telomerase activity in tumours and tumour adjacent tissues may be better parameter of tumour agresivity than standard grading.
Abstract (in Czech)
U 58 pacientů s nádory hlavy a krku byla stanovována aktivita telomerázy kvantitativní metodou, kdy byla telomeráza detekována u 88 % nádorů. Hodnota aktivity telomerázy byla srovnávána se standardními histopatologickými parametry (velikost nádoru, stupeň rozšíření nádoru do lymfatického systému a diferenciace nádoru). Bylo zjištěno, že aktivita telomerázy stanovená u nádoru a jeho okolní tkáně může být přesnějším ukazatelem agresivity nádoru, než parametr určující stupeň diferenciace nádoru (grade).
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