KONOPKA, Roman, Lukáš KUBALA, Antonín LOJEK and Jiří PACHERNÍK. Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production. NEUROENDOCRINOLOGY LETTERS. 2008 Oct;29(5):770-4, 2008, vol. 29, No 5, p. 770-774. ISSN 0172-780X.
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Basic information
Original name Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production
Authors KONOPKA, Roman (203 Czech Republic, belonging to the institution), Lukáš KUBALA (203 Czech Republic, guarantor, belonging to the institution), Antonín LOJEK (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, belonging to the institution).
Edition NEUROENDOCRINOLOGY LETTERS, 2008 Oct;29(5):770-4, 2008, 0172-780X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Sweden
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.359
RIV identification code RIV/00216224:14310/08:00049587
Organization unit Faculty of Science
UT WoS 000261553200033
Keywords in English embryonal carcinoma cells; neural differentiation; redox status; antioxidants
Tags Pb, rivok
Changed by Changed by: Ing. Andrea Mikešková, učo 137293. Changed: 20/4/2012 09:25.
Abstract
Intracellularly generated reactive oxygen species (ROS) are thought to modulate redox sensitive signaling pathways and thus regulate cell physiology including proliferation and differentiation. However, the role of ROS in neuronal differentiation of embryonic pluripotent cells is unknown. For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated.
Links
GP524/03/P171, research and development projectName: Mechanismy řídící neurální diferenciaci myších embryonálních kmenových buněk in vitro
Investor: Czech Science Foundation
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