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@proceedings{822800,
author = {Horký, Ondřej and Mayer, Jiří and Kablásková, Lenka and Borský, Marek and Ohlídalová, Dana and Krejčí, Marta and Dvořáková, Dana},
booktitle = {Haematologica-the hematology journal},
keywords = {mikrochimerism; relapse; prediction},
language = {eng},
title = {MICROCHIMERISM - LOOK INTO THE INCIPIENT AML RELAPSE?},
year = {2008}
}
TY - CONF
ID - 822800
AU - Horký, Ondřej - Mayer, Jiří - Kablásková, Lenka - Borský, Marek - Ohlídalová, Dana - Krejčí, Marta - Dvořáková, Dana
PY - 2008
TI - MICROCHIMERISM - LOOK INTO THE INCIPIENT AML RELAPSE?
KW - mikrochimerism
KW - relapse
KW - prediction
N2 - The reoccurrence or increase in autologous hematopoiesis after an allogeneic hematopoietic cell transplantation (allo-HCT) has been linked with incipient leukemia relapse, however, clear definition of such "emergency" in terms of microchimerism has not been defined yet. Aims Since the usual minimal residual disease (MRD) analysis is more sensitive than conventional chimerism analysis and MRD-guided intervention is routinely used after transplantation, here we wanted to explore if more sensitive chimerism analysis (microchimerism) could be used for earlier detection of imminent relapse. Methods We compared conventional polymerase chain reaction (PCR) of minisatellite, microsatellite, or sex specific regions with following fragment analysis (FA) (limit of quantification ~1%), with real-time quantitative PCR (RQ-PCR) of insertion/deletion and sex polymorphism (limit of quantification ~0.1%).
ER -
HORKÝ, Ondřej, Jiří MAYER, Lenka KABLÁSKOVÁ, Marek BORSKÝ, Dana OHLÍDALOVÁ, Marta KREJČÍ and Dana DVOŘÁKOVÁ. MICROCHIMERISM - LOOK INTO THE INCIPIENT AML RELAPSE? In \textit{Haematologica-the hematology journal}. 2008. ISSN~0390-6078.
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