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@article{827564,
author = {Novák, Jiří and Beníšek, Martin and Hilscherová, Klára},
article_location = {Amsterdam, The Netherlands},
article_number = {6},
keywords = {vitamin A; all-trans retinoic acid; pesticide; TCDD; polychlorinated biphenyls; retinoids},
language = {eng},
issn = {0160-4120},
journal = {Environment International},
title = {Disruption of retinoid transport, metabolism and signaling by environmental pollutants},
volume = {34},
year = {2008}
}
TY - JOUR
ID - 827564
AU - Novák, Jiří - Beníšek, Martin - Hilscherová, Klára
PY - 2008
TI - Disruption of retinoid transport, metabolism and signaling by environmental pollutants
JF - Environment International
VL - 34
IS - 6
SP - 898-913
EP - 898-913
PB - Elsevier
SN - 01604120
KW - vitamin A
KW - all-trans retinoic acid
KW - pesticide
KW - TCDD
KW - polychlorinated biphenyls
KW - retinoids
N2 - Disruption of retinoid transport, metabolism and signaling by environmental pollutants. - a review. Although the assessment of circulatory levels of retinoids has become a widely used biomarker of exposure to environmental pollutants, the adverse effects caused by imbalance of the retinoid metabolism and signaling in wildlife are not known in detail. Retinoids play an important role in controlling such vital processes as morphogenesis, development, reproduction or apoptosis. Unlike other signaling molecules, retinoids are not strictly endogenous but they are derived from dietary sources of vitamin A or its precursors and thus they are sometimes referred to as dietary hormones. Some environmental pollutants that affect embryogenesis, immunity or epithelial functions were also shown to interfere with retinoid metabolism and signaling in animals. This suggests that at least some of their toxic effects may be associated with interaction with the retinoid metabolism, transport or signal transduction. This review summarizes in vivo and in vitro studies on interaction of environmental complex samples, pesticides, polychlorinated dioxins, polychlorinated biphenyls, polycyclic aromatic compounds and other organic pollutants with metabolism and signaling of retinoids. It sums up contemporary knowledge about levels of interaction and mechanisms of action of the environmental contaminants.
ER -
NOVÁK, Jiří, Martin BENÍŠEK a Klára HILSCHEROVÁ. Disruption of retinoid transport, metabolism and signaling by environmental pollutants. \textit{Environment International}. Amsterdam, The Netherlands: Elsevier, 2008, roč.~34, č.~6, s.~898-913. ISSN~0160-4120.
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