Reduced memory B cells in patients with hyper IgE syndrome

J 2008

Reduced memory B cells in patients with hyper IgE syndrome

SPECKMANN, C.; A. ENDERS; C. WOELLNER; D. THIEL; A. RENSING-EHL et al.

Základní údaje

Originální název

Reduced memory B cells in patients with hyper IgE syndrome

Název česky

Snížení počtu paměťových B- lymfocytů u nemocných s hyper IgE syndromem

Autoři

Vydání

Clin Immunol, 2008, 1521-6616

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.606

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/08:00035423

Organizační jednotka

Lékařská fakulta

UT WoS

000261011100008

Klíčová slova česky

Hyper IgE syndrom; B buňky; STAT-3; paměťové buňky

Klíčová slova anglicky

Hyper IgE syndrome; B cells; STAT-3; Memory cells

Štítky

B cells, hyper IgE syndrome, Memory cells, STAT-3

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 4. 2010 08:01, prof. MUDr. Jiří Litzman, CSc.

Anotace

ORIG CZ

V originále

Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

Česky

U pacientů s hyper IgE syndromem je snížen počet paměťových B-lymfocytů.

Citovat

SPECKMANN, C.; A. ENDERS; C. WOELLNER; D. THIEL; A. RENSING-EHL; M. SCHLESIER; J. ROHR; T. JAKOB; E. OSWALD; M.V. KOPP; O. SANAL; Jiří LITZMAN; A. PLEBANI; M.C. PIETROGRANDE; J.L. FRANCO; T. ESPANOL; B. GRIMBACHER a S. EHL. Reduced memory B cells in patients with hyper IgE syndrome. Clin Immunol. 2008, roč. 129, č. 3, s. 448-454. ISSN 1521-6616.

@article{829395,
   author = {Speckmann, C. and Enders, A. and Woellner, C. and Thiel, D. and RensingandEhl, A. and Schlesier, M. and Rohr, J. and Jakob, T. and Oswald, E. and Kopp, M.V. and Sanal, O. and Litzman, Jiří and Plebani, A. and Pietrogrande, M.C. and Franco, J.L. and Espanol, T. and Grimbacher, B. and Ehl, S.},
   article_number = {3},
   keywords = {Hyper IgE syndrome; B cells; STAT-3; Memory cells},
   language = {eng},
   issn = {1521-6616},
   journal = {Clin Immunol},
   title = {Reduced memory B cells in patients with hyper IgE syndrome},
   volume = {129},
   year = {2008}
}

TY  - JOUR
ID  - 829395
AU  - Speckmann, C. - Enders, A. - Woellner, C. - Thiel, D. - Rensing-Ehl, A. - Schlesier, M. - Rohr, J. - Jakob, T. - Oswald, E. - Kopp, M.V. - Sanal, O. - Litzman, Jiří - Plebani, A. - Pietrogrande, M.C. - Franco, J.L. - Espanol, T. - Grimbacher, B. - Ehl, S.
PY  - 2008
TI  - Reduced memory B cells in patients with hyper IgE syndrome
JF  - Clin Immunol
VL  - 129
IS  - 3
SP  - 448-454
EP  - 448-454
SN  - 15216616
KW  - Hyper IgE syndrome
KW  - B cells
KW  - STAT-3
KW  - Memory cells
N2  - Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.
ER  -

SPECKMANN, C.; A. ENDERS; C. WOELLNER; D. THIEL; A. RENSING-EHL; M. SCHLESIER; J. ROHR; T. JAKOB; E. OSWALD; M.V. KOPP; O. SANAL; Jiří LITZMAN; A. PLEBANI; M.C. PIETROGRANDE; J.L. FRANCO; T. ESPANOL; B. GRIMBACHER a S. EHL. Reduced memory B cells in patients with hyper IgE syndrome. \textit{Clin Immunol}. 2008, roč.~129, č.~3, s.~448-454. ISSN~1521-6616.

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