| YANG, Dong-Hwa, Ju-Young YOON, Soung-Hoon LEE, Vítězslav BRYJA, Emma R. ANDERSSON, Ernest ARENAS, Young-Guen KWON a Kang-Yell CHOI. Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa. Circulation Research. 2009, roč. 104, č. 3, s. 372-379. ISSN 1524-4571. |
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@article{830004,
author = {Yang, DongandHwa and Yoon, JuandYoung and Lee, SoungandHoon and Bryja, Vítězslav and Andersson, Emma R. and Arenas, Ernest and Kwon, YoungandGuen and Choi, KangandYell},
article_number = {3},
keywords = {Wnt5a; embryonic stem cells; beta-catenin; PKC alfa; endothelial defferentiation},
language = {eng},
issn = {1524-4571},
journal = {Circulation Research},
title = {Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa},
volume = {104},
year = {2009}
}
TY - JOUR
ID - 830004
AU - Yang, Dong-Hwa - Yoon, Ju-Young - Lee, Soung-Hoon - Bryja, Vítězslav - Andersson, Emma R. - Arenas, Ernest - Kwon, Young-Guen - Choi, Kang-Yell
PY - 2009
TI - Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa
JF - Circulation Research
VL - 104
IS - 3
SP - 372-379
EP - 372-379
SN - 15244571
KW - Wnt5a
KW - embryonic stem cells
KW - beta-catenin
KW - PKC alfa
KW - endothelial defferentiation
N2 - In this study, we examined the signaling pathways activated by Wnt5a in endothelial differentiation of embryonic stem (ES) cells and the function of Wnt5a during vascular development. We first found that Wnt5a(-/-) mouse embryonic stem (mES) cells exhibited a defect in endothelial differentiation, which was rescued by addition of Wnt5a, suggesting that Wnt5a is required for endothelial differentiation of ES cells. Furthermore, a defect in the vascularization of the neural tissue was detected at embryonic day 14.5 in Wnt5a(-/-) mice, implicating Wnt5a in vascular development in vivo. Thus, we conclude that Wnt5a is involved in the endothelial differentiation of ES cells via both Wnt/beta-catenin and PKC signaling pathways and regulates embryonic vascular development.
ER -
YANG, Dong-Hwa, Ju-Young YOON, Soung-Hoon LEE, Vítězslav BRYJA, Emma R. ANDERSSON, Ernest ARENAS, Young-Guen KWON a Kang-Yell CHOI. Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa. \textit{Circulation Research}. 2009, roč.~104, č.~3, s.~372-379. ISSN~1524-4571.
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