Diversity of prophages in dominant Staphylococcus aureus>
clonal lineages

J 2009

Diversity of prophages in dominant Staphylococcus aureus> clonal lineages

GOERKE, Christiane, Roman PANTŮČEK, Silvia HOLTFRETER, Berit SCHULTE, Manuel ZINK et. al.

Základní údaje

Originální název

Diversity of prophages in dominant Staphylococcus aureus> clonal lineages

Název česky

Rozmanitost profágů u dominantních klonálních linií Staphylococcus aureus

Autoři

GOERKE, Christiane (276 Německo), Roman PANTŮČEK (203 Česká republika, garant), Silvia HOLTFRETER (276 Německo), Berit SCHULTE (276 Německo), Manuel ZINK (276 Německo), Dorothee GRUMANN (276 Německo), Barbara M. BRÖKER (276 Německo), Jiří DOŠKAŘ (203 Česká republika) a Christiane WOLZ (276 Německo)

Vydání

Journal of Bacteriology, Washington, D.C. American Society for Microbiology, 2009, 0021-9193

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

[PDF] [URL]

Impakt faktor

Impact factor: 3.940

Kód RIV

RIV/00216224:14310/09:00035545

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000266041300005

Klíčová slova anglicky

Staphylococcus aureus; bacteriophages; accessory genome; clonal lineages; lysogeny

Štítky

accessory genome, bacteriophages, clonal lineages, Lysogeny, Staphylococcus aureus

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 10. 2010 16:28, prof. RNDr. Roman Pantůček, Ph.D.

Anotace

ORIG CZ

V originále

Temperate bacteriophages play an important role in the pathogenicity of Staphylococcus aureus, for instance, by mediating the horizontal gene transfer of virulence factors. Here we established a classification scheme for staphylococcal prophages of the major Siphoviridae family based on integrase gene polymorphism. Seventy-one published genome sequences of staphylococcal phages were clustered into distinct integrase groups which were related to the chromosomal integration site and to the encoded virulence gene content. Analysis of three marker modules (lysogeny, tail, and lysis) for phage functional units revealed that these phages exhibit different degrees of genome mosaicism. The prevalence of prophages in a representative S. aureus strain collection consisting of 386 isolates of diverse origin was determined. By linking the phage content to dominant S. aureus clonal complexes we could show that the distribution of bacteriophages varied remarkably between lineages, indicating restriction-based barriers. A comparison of colonizing and invasive S. aureus strain populations revealed that hlb-converting phages were significantly more frequent in colonizing strains.

Česky

Temperované fágy hrají významnou úlohu v patogenitě Staphylococcus aureus, např. zprostředkovávají horizontální přenos genů virulence a rezistence. V této práci navrhujeme klasifikační schéma profágů čeledi siphoviridae na základě polymorfizmu genu pro integrázu.

Návaznosti

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

Citovat

GOERKE, Christiane, Roman PANTŮČEK, Silvia HOLTFRETER, Berit SCHULTE, Manuel ZINK, Dorothee GRUMANN, Barbara M. BRÖKER, Jiří DOŠKAŘ a Christiane WOLZ. Diversity of prophages in dominant Staphylococcus aureus> clonal lineages. Journal of Bacteriology. Washington, D.C.: American Society for Microbiology, 2009, roč. 191, č. 11, s. 3462-3468. ISSN 0021-9193.

@article{832297,
   author = {Goerke, Christiane and Pantůček, Roman and Holtfreter, Silvia and Schulte, Berit and Zink, Manuel and Grumann, Dorothee and Bröker, Barbara M. and Doškař, Jiří and Wolz, Christiane},
   article_location = {Washington, D.C.},
   article_number = {11},
   keywords = {Staphylococcus aureus; bacteriophages; accessory genome; clonal lineages; lysogeny},
   language = {eng},
   issn = {0021-9193},
   journal = {Journal of Bacteriology},
   title = {Diversity of prophages in dominant Staphylococcus aureus> clonal lineages},
   url = {http://jb.asm.org/cgi/content/full/191/11/3462},
   volume = {191},
   year = {2009}
}

TY  - JOUR
ID  - 832297
AU  - Goerke, Christiane - Pantůček, Roman - Holtfreter, Silvia - Schulte, Berit - Zink, Manuel - Grumann, Dorothee - Bröker, Barbara M. - Doškař, Jiří - Wolz, Christiane
PY  - 2009
TI  - Diversity of prophages in dominant Staphylococcus aureus> clonal lineages
JF  - Journal of Bacteriology
VL  - 191
IS  - 11
SP  - 3462-3468
EP  - 3462-3468
PB  - American Society for Microbiology
SN  - 00219193
KW  - Staphylococcus aureus
KW  - bacteriophages
KW  - accessory genome
KW  - clonal lineages
KW  - lysogeny
UR  - http://jb.asm.org/cgi/content/full/191/11/3462
N2  - Temperate bacteriophages play an important role in the pathogenicity of Staphylococcus aureus, for instance, by mediating the horizontal gene transfer of virulence factors. Here we established a classification scheme for staphylococcal prophages of the major Siphoviridae family based on integrase gene polymorphism. Seventy-one published genome sequences of staphylococcal phages were clustered into distinct integrase groups which were related to the chromosomal integration site and to the encoded virulence gene content. Analysis of three marker modules (lysogeny, tail, and lysis) for phage functional units revealed that these phages exhibit different degrees of genome mosaicism. The prevalence of prophages in a representative S. aureus strain collection consisting of 386 isolates of diverse origin was determined. By linking the phage content to dominant S. aureus clonal complexes we could show that the distribution of bacteriophages varied remarkably between lineages, indicating restriction-based barriers. A comparison of colonizing and invasive S. aureus strain populations revealed that hlb-converting phages were significantly more frequent in colonizing strains.
ER  -

GOERKE, Christiane, Roman PANTŮČEK, Silvia HOLTFRETER, Berit SCHULTE, Manuel ZINK, Dorothee GRUMANN, Barbara M. BRÖKER, Jiří DOŠKAŘ a Christiane WOLZ. Diversity of prophages in dominant Staphylococcus aureus$>$ clonal lineages. \textit{Journal of Bacteriology}. Washington, D.C.: American Society for Microbiology, 2009, roč.~191, č.~11, s.~3462-3468. ISSN~0021-9193.

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