Activation via the antigen receptor is impaired in T cells, but
not in B cells from patients with common variable
immunodeficiency

J 1996

Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency

FISCHER, MB.; HM. WOLF; I. HAUBER; H. EGGENBAUER; Vojtěch THON et al.

Základní údaje

Originální název

Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency

Název česky

Aktivace cestou antigenního receptoru je porušena u T buněk, avšak ne u B buněk pacientů s běžnou variabilní imunodeficiencí

Autoři

FISCHER, MB.; HM. WOLF; I. HAUBER; H. EGGENBAUER; Vojtěch THON; M. SASGARY a MM. EIBL

Vydání

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 0014-2980

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/96:00035801

Organizační jednotka

Lékařská fakulta

UT WoS

A1996UD13800035

Klíčová slova česky

TCR; CVID

Klíčová slova anglicky

T cell activation; common variable immunodeficiency; T cell receptor; inositol phosphates

Štítky

common variable immunodeficiency, inositol phosphates, T cell activation, T cell receptor

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 00:18, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

The patients included in this study belong to a subset of common variable immunodeficiency (CVID) patients whose peripheral blood T cells have a T cell receptor (TCR)-mediated activation defect leading to impaired expression of the interleukin (IL)-2 gene upon stimulation with recall antigens (tetanus toxoid, Escherichia coli) or superantigens (staphy lococcal enterotoxins). In the present report we demonstrate that the patients' peripheral blood T cells failed to generate the second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P-3) following stimulation with superantigen or mAb specific for the monomorphic region of the TCR beta-chain. Patients' T cell lines were also impaired in generating Ins(1,4,5)P, when stimulated with tetanus toxoid-pulsed autologous monocytes. Addition of a second or third co-stimulatory signal provided by recombinant IL-2, CD28 or both had no effect on the Ins(1,4)P-3 formation of the patients' antigen-driven T cell lines. The T cell activation defect, however, was not absolute, as Ins(1,4,5)P-3 formation in the patients T cells after phytohemagglutinin or aluminium fluoride stimulation was normal. The impairment in signal transduction via the T cell antigen receptor was limited to the patients' T cells, as no activation defect after ligation of surface immunoglobulin. the antigen receptor on B cells, could be detected.

Česky

Aktivace cestou antigenního receptoru je porušena u T buněk, avšak ne u B buněk pacientů s běžnou variabilní imunodeficiencí.

Citovat

FISCHER, MB.; HM. WOLF; I. HAUBER; H. EGGENBAUER; Vojtěch THON; M. SASGARY a MM. EIBL. Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency. EUROPEAN JOURNAL OF IMMUNOLOGY. 1996, roč. 26, č. 1, s. 231-237. ISSN 0014-2980.

@article{837107,
   author = {Fischer, MB. and Wolf, HM. and Hauber, I. and Eggenbauer, H. and Thon, Vojtěch and Sasgary, M. and Eibl, MM.},
   article_number = {1},
   keywords = {T cell activation; common variable immunodeficiency; T cell receptor; inositol phosphates},
   language = {eng},
   issn = {0014-2980},
   journal = {EUROPEAN JOURNAL OF IMMUNOLOGY},
   title = {Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency},
   volume = {26},
   year = {1996}
}

TY  - JOUR
ID  - 837107
AU  - Fischer, MB. - Wolf, HM. - Hauber, I. - Eggenbauer, H. - Thon, Vojtěch - Sasgary, M. - Eibl, MM.
PY  - 1996
TI  - Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency
JF  - EUROPEAN JOURNAL OF IMMUNOLOGY
VL  - 26
IS  - 1
SP  - 231-237
EP  - 231-237
SN  - 00142980
KW  - T cell activation
KW  - common variable immunodeficiency
KW  - T cell receptor
KW  - inositol phosphates
N2  - The patients included in this study belong to a subset of common variable immunodeficiency (CVID) patients whose peripheral blood T cells have a T cell receptor (TCR)-mediated activation defect leading to impaired expression of the interleukin (IL)-2 gene upon stimulation with recall antigens (tetanus toxoid, Escherichia coli) or superantigens (staphy lococcal enterotoxins). In the present report we demonstrate that the patients' peripheral blood T cells failed to generate the second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P-3) following stimulation with superantigen or mAb specific for the monomorphic region of the TCR beta-chain. Patients' T cell lines were also impaired in generating Ins(1,4,5)P, when stimulated with tetanus toxoid-pulsed autologous monocytes. Addition of a second or third co-stimulatory signal provided by recombinant IL-2, CD28 or both had no effect on the Ins(1,4)P-3 formation of the patients' antigen-driven T cell lines. The T cell activation defect, however, was not absolute, as Ins(1,4,5)P-3 formation in the patients T cells after phytohemagglutinin or aluminium fluoride stimulation was normal. The impairment in signal transduction via the T cell antigen receptor was limited to the patients' T cells, as no activation defect after ligation of surface immunoglobulin. the antigen receptor on B cells, could be detected.
ER  -

FISCHER, MB.; HM. WOLF; I. HAUBER; H. EGGENBAUER; Vojtěch THON; M. SASGARY a MM. EIBL. Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency. \textit{EUROPEAN JOURNAL OF IMMUNOLOGY}. 1996, roč.~26, č.~1, s.~231-237. ISSN~0014-2980.

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