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@article{837107,
author = {Fischer, MB. and Wolf, HM. and Hauber, I. and Eggenbauer, H. and Thon, Vojtěch and Sasgary, M. and Eibl, MM.},
article_number = {1},
keywords = {T cell activation; common variable immunodeficiency; T cell receptor; inositol phosphates},
language = {eng},
issn = {0014-2980},
journal = {EUROPEAN JOURNAL OF IMMUNOLOGY},
title = {Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency},
volume = {26},
year = {1996}
}
TY - JOUR
ID - 837107
AU - Fischer, MB. - Wolf, HM. - Hauber, I. - Eggenbauer, H. - Thon, Vojtěch - Sasgary, M. - Eibl, MM.
PY - 1996
TI - Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency
JF - EUROPEAN JOURNAL OF IMMUNOLOGY
VL - 26
IS - 1
SP - 231-237
EP - 231-237
SN - 00142980
KW - T cell activation
KW - common variable immunodeficiency
KW - T cell receptor
KW - inositol phosphates
N2 - The patients included in this study belong to a subset of common variable immunodeficiency (CVID) patients whose peripheral blood T cells have a T cell receptor (TCR)-mediated activation defect leading to impaired expression of the interleukin (IL)-2 gene upon stimulation with recall antigens (tetanus toxoid, Escherichia coli) or superantigens (staphy lococcal enterotoxins). In the present report we demonstrate that the patients' peripheral blood T cells failed to generate the second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P-3) following stimulation with superantigen or mAb specific for the monomorphic region of the TCR beta-chain. Patients' T cell lines were also impaired in generating Ins(1,4,5)P, when stimulated with tetanus toxoid-pulsed autologous monocytes. Addition of a second or third co-stimulatory signal provided by recombinant IL-2, CD28 or both had no effect on the Ins(1,4)P-3 formation of the patients' antigen-driven T cell lines. The T cell activation defect, however, was not absolute, as Ins(1,4,5)P-3 formation in the patients T cells after phytohemagglutinin or aluminium fluoride stimulation was normal. The impairment in signal transduction via the T cell antigen receptor was limited to the patients' T cells, as no activation defect after ligation of surface immunoglobulin. the antigen receptor on B cells, could be detected.
ER -
FISCHER, MB., HM. WOLF, I. HAUBER, H. EGGENBAUER, Vojtěch THON, M. SASGARY a MM. EIBL. Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency. \textit{EUROPEAN JOURNAL OF IMMUNOLOGY}. 1996, roč.~26, č.~1, s.~231-237. ISSN~0014-2980.
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