DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR
BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA

J 1995

DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA

FISCHER, MB.; I. HAUBER; M. FODINGER; HM. WOLF; Vojtěch THON et al.

Základní údaje

Originální název

DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA

Název česky

Porušená exprese TCR asociovaná s poruchou beta řetězce receptoru TCR u pacienta s kožním T buněčným lymfomem

Autoři

FISCHER, MB.; I. HAUBER; M. FODINGER; HM. WOLF; Vojtěch THON; P. DONATH; MM. EIBL a RM, KNOBLER

Vydání

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 0022-202X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/95:00035802

Organizační jednotka

Lékařská fakulta

UT WoS

A1995QR53200021

Klíčová slova česky

TCR; T lymfom

Klíčová slova anglicky

RECEPTOR COMPLEX; LYMPHOCYTES T; ANTIGEN; SEQUENCE; SUBUNITS; T cell lymphoma

Štítky

ANTIGEN, LYMPHOCYTES T, RECEPTOR COMPLEX, SEQUENCE, SUBUNITS, T cell lymphoma

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 00:25, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

We report on a patient with cutaneous T-cell lymphoma (CTCL) of long-standing duration. Phenotypic analysis of his peripheral blood mononuclear cells revealed an increased CD4(+) T-helper subset and a decreased CD8(+) cytotoxic T-cell population. Eighty-three to ninety-three percent of the patient's CD4(+) T cells in the peripheral blood and 70% of the CD4(+) T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2). The lack in TCR surface expression correlated with defective assembly of the TCR beta-chain. Although mRNA for the TCR constant region beta 1 was found in the patient's purified CD4(+)TCR(-)CD3(-) T cells, no intracytoplasmic TCR beta protein was detectable. In contrast, the patient's purified CD4(+)TCR(-)CD3(-) T cells not only expressed mRNA specific for the TCR alpha-chain and for all CD3 chains, but intracytoplasmic TCR alpha and CD3 epsilon proteins could also be found. The lack of TCR beta protein clearly explains the defective surface expression of the TCR/CD3 complex in the patient's malignant T cells.

Česky

Porušená exprese TCR asociovaná s poruchou beta řetězce receptoru TCR u pacienta s kožním T buněčným lymfomem.

Citovat

FISCHER, MB.; I. HAUBER; M. FODINGER; HM. WOLF; Vojtěch THON; P. DONATH; MM. EIBL a RM, KNOBLER. DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1995, roč. 104, č. 4, s. 537-540. ISSN 0022-202X.

@article{837108,
   author = {Fischer, MB. and Hauber, I. and Fodinger, M. and Wolf, HM. and Thon, Vojtěch and Donath, P. and Eibl, MM. and Knobler, RM,},
   article_number = {4},
   keywords = {RECEPTOR COMPLEX; LYMPHOCYTES T; ANTIGEN; SEQUENCE; SUBUNITS; T cell lymphoma},
   language = {eng},
   issn = {0022-202X},
   journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
   title = {DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA},
   volume = {104},
   year = {1995}
}

TY  - JOUR
ID  - 837108
AU  - Fischer, MB. - Hauber, I. - Fodinger, M. - Wolf, HM. - Thon, Vojtěch - Donath, P. - Eibl, MM. - Knobler, RM,
PY  - 1995
TI  - DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA
JF  - JOURNAL OF INVESTIGATIVE DERMATOLOGY
VL  - 104
IS  - 4
SP  - 537-540
EP  - 537-540
SN  - 0022202X
KW  - RECEPTOR COMPLEX
KW  - LYMPHOCYTES T
KW  - ANTIGEN
KW  - SEQUENCE
KW  - SUBUNITS
KW  - T cell lymphoma
N2  - We report on a patient with cutaneous T-cell lymphoma (CTCL) of long-standing duration. Phenotypic analysis of his peripheral blood mononuclear cells revealed an increased CD4(+) T-helper subset and a decreased CD8(+) cytotoxic T-cell population. Eighty-three to ninety-three percent of the patient's CD4(+) T cells in the peripheral blood and 70% of the CD4(+) T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2). The lack in TCR surface expression correlated with defective assembly of the TCR beta-chain. Although mRNA for the TCR constant region beta 1 was found in the patient's purified CD4(+)TCR(-)CD3(-) T cells, no intracytoplasmic TCR beta protein was detectable. In contrast, the patient's purified CD4(+)TCR(-)CD3(-) T cells not only expressed mRNA specific for the TCR alpha-chain and for all CD3 chains, but intracytoplasmic TCR alpha and CD3 epsilon proteins could also be found. The lack of TCR beta protein clearly explains the defective surface expression of the TCR/CD3 complex in the patient's malignant T cells.
ER  -

FISCHER, MB.; I. HAUBER; M. FODINGER; HM. WOLF; Vojtěch THON; P. DONATH; MM. EIBL a RM, KNOBLER. DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA. \textit{JOURNAL OF INVESTIGATIVE DERMATOLOGY}. 1995, roč.~104, č.~4, s.~537-540. ISSN~0022-202X.

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