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@article{837118,
author = {Litzman, J. and Burianova, M. and Thon, Vojtěch and Lokaj, J.},
article_number = {4},
keywords = {IgA deficiency; CVID;},
language = {eng},
issn = {0301-0546},
journal = {Allergologia et immunopathologia},
title = {Progression of selective IgA deficiency to common variable immunodeficiency in a 16 year old boy.},
volume = {24},
year = {1996}
}
TY - JOUR
ID - 837118
AU - Litzman, J. - Burianova, M. - Thon, Vojtěch - Lokaj, J.
PY - 1996
TI - Progression of selective IgA deficiency to common variable immunodeficiency in a 16 year old boy.
JF - Allergologia et immunopathologia
VL - 24
IS - 4
SP - 174-176
EP - 174-176
SN - 03010546
KW - IgA deficiency
KW - CVID;
N2 - A case report of a 16 year old boy in whom selective IgA deficiency progressed to typical common variable immunodeficiency (CVID) is described. This boy with a history of frequent but not severe respiratory tract infections was referred to hospital because of severe pleuropneumonia and decreased levels of IgA (0.23 g/L), but normal IgG and IgM levels. Lymphocyte subpopulation determination revealed a decreased proportion of CD4+ lymphocytes (30%) and an increased proportion of CD8+ lymphocytes (32%), while CD3+, CD19+ and CD16+/56+ subpopulations were normal. During the subsequent 17 months a gradual decrease in IgG (ultimate level 2.23 g/L), IgA (< 0.05 g/L) and IgM (< 0.05 g/L) levels was observed, the decrease in IgM being the slowest reflecting a constant heavy chain gene order on chromosome 14. The observation supports the thesis of a close relation of selective IgA deficiency and common variable immunodeficiency.
ER -
LITZMAN, J., M. BURIANOVA, Vojtěch THON a J. LOKAJ. Progression of selective IgA deficiency to common variable immunodeficiency in a 16 year old boy. \textit{Allergologia et immunopathologia}. 1996, roč.~24, č.~4, s.~174-176. ISSN~0301-0546.
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