NOVÁKOVÁ, Jana, Ondřej SLABÝ, Rostislav VYZULA and Jaroslav MICHÁLEK. MicroRNA involvement in glioblastoma pathogenesis. Biochemical and Biophysical Research Communications. San Diego (USA): Elsevier, 2009, vol. 386, No 1, p. 1-5. ISSN 0006-291X.
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Basic information
Original name MicroRNA involvement in glioblastoma pathogenesis
Name in Czech Zapojení mikroRNA do patogeneze glioblastomu
Authors NOVÁKOVÁ, Jana (203 Czech Republic), Ondřej SLABÝ (203 Czech Republic, guarantor), Rostislav VYZULA (203 Czech Republic) and Jaroslav MICHÁLEK (203 Czech Republic).
Edition Biochemical and Biophysical Research Communications, San Diego (USA), Elsevier, 2009, 0006-291X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Greece
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.548
RIV identification code RIV/00216224:14110/09:00035862
Organization unit Faculty of Medicine
UT WoS 000267868800001
Keywords (in Czech) mikroRNA; glioblastom; patogeneze; apoptoza; buněčný cyklus
Keywords in English MicroRNA; Glioblastoma;Pathogenesis;Apoptosis;Cell cycle
Tags apoptosis, cell cycle, Glioblastoma, microRNA, pathogenesis
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Ondřej Slabý, Ph.D., učo 42891. Changed: 30/9/2010 15:41.
Abstract
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.
Abstract (in Czech)
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.
Links
NS9875, research and development projectName: Studium mechanismu imunorezistence glioblastomu
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