Versatile templates for the development of novel kinase
inhibitors: Discovery of novel CDK inhibitors

J 2007

Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors

DWYER, Michael, Kamil PARUCH, Carmen ALVAREZ, Ronald DOLL, Kerry KEERTIKAR et. al.

Základní údaje

Originální název

Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors

Název česky

Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors

Autoři

DWYER, Michael (840 Spojené státy), Kamil PARUCH (203 Česká republika, garant), Carmen ALVAREZ (840 Spojené státy), Ronald DOLL (840 Spojené státy), Kerry KEERTIKAR (840 Spojené státy), Jose DUCA (840 Spojené státy), Thierry FISCHMANN (840 Spojené státy), Alan HRUZA (840 Spojené státy), Vincent MADISON (840 Spojené státy), Emma LEES (840 Spojené státy), David PARRY (840 Spojené státy), Wolfgang SEGHEZZI (840 Spojené státy), Nicole SGAMBELLONE (840 Spojené státy), Frances SHANAHAN (840 Spojené státy), Derek WISWELL (840 Spojené státy) a Timothy GUZI (840 Spojené státy)

Vydání

Bioorganic & Medicinal Chemistry Letters, 2007, 0960-894X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.604

Kód RIV

RIV/00216224:14310/07:00035882

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000250906200035

Klíčová slova česky

kinázy; templát; CDK2

Klíčová slova anglicky

kinases; template; CDK2

Štítky

CDK2, kinases, template

Příznaky

Recenzováno

Změněno: 25. 6. 2009 16:15, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

A series of four bicyclic cores were prepared and evaluated and cyclin-dependent kinase-2 (CDK2) inhibitors. From the in vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior for further elaboration in the identification of novel CDK2 inhibitors.

Česky

viz anotace

Citovat

DWYER, Michael, Kamil PARUCH, Carmen ALVAREZ, Ronald DOLL, Kerry KEERTIKAR, Jose DUCA, Thierry FISCHMANN, Alan HRUZA, Vincent MADISON, Emma LEES, David PARRY, Wolfgang SEGHEZZI, Nicole SGAMBELLONE, Frances SHANAHAN, Derek WISWELL a Timothy GUZI. Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors. Bioorganic & Medicinal Chemistry Letters. 2007, roč. 2007, č. 17, s. 6216-6219. ISSN 0960-894X.

@article{837821,
   author = {Dwyer, Michael and Paruch, Kamil and Alvarez, Carmen and Doll, Ronald and Keertikar, Kerry and Duca, Jose and Fischmann, Thierry and Hruza, Alan and Madison, Vincent and Lees, Emma and Parry, David and Seghezzi, Wolfgang and Sgambellone, Nicole and Shanahan, Frances and Wiswell, Derek and Guzi, Timothy},
   article_number = {17},
   keywords = {kinases; template; CDK2},
   language = {eng},
   issn = {0960-894X},
   journal = {Bioorganic & Medicinal Chemistry Letters},
   title = {Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors},
   volume = {2007},
   year = {2007}
}

TY  - JOUR
ID  - 837821
AU  - Dwyer, Michael - Paruch, Kamil - Alvarez, Carmen - Doll, Ronald - Keertikar, Kerry - Duca, Jose - Fischmann, Thierry - Hruza, Alan - Madison, Vincent - Lees, Emma - Parry, David - Seghezzi, Wolfgang - Sgambellone, Nicole - Shanahan, Frances - Wiswell, Derek - Guzi, Timothy
PY  - 2007
TI  - Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
JF  - Bioorganic & Medicinal Chemistry Letters
VL  - 2007
IS  - 17
SP  - 6216-6219
EP  - 6216-6219
SN  - 0960894X
KW  - kinases
KW  - template
KW  - CDK2
N2  - A series of four bicyclic cores were prepared and evaluated and cyclin-dependent kinase-2 (CDK2) inhibitors. From the in vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior for further elaboration in the identification of novel CDK2 inhibitors.
ER  -

DWYER, Michael, Kamil PARUCH, Carmen ALVAREZ, Ronald DOLL, Kerry KEERTIKAR, Jose DUCA, Thierry FISCHMANN, Alan HRUZA, Vincent MADISON, Emma LEES, David PARRY, Wolfgang SEGHEZZI, Nicole SGAMBELLONE, Frances SHANAHAN, Derek WISWELL a Timothy GUZI. Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors. \textit{Bioorganic \&{} Medicinal Chemistry Letters}. 2007, roč.~2007, č.~17, s.~6216-6219. ISSN~0960-894X.

Podrobný výpis o publikaci