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@article{837975,
author = {Krejčí, Marta and Büchler, Tomáš and Hájek, Roman and Svobodník, A. and Křivanová, Andrea and Pour, Luděk and Adam, Zdeněk and Mayer, Jiří and Vorlíček, Jiří},
article_location = {London},
article_number = {2},
keywords = {multiple myeloma; autologous stem cell transplantation},
language = {eng},
issn = {0268-3369},
journal = {Bone Marrow Transplantation},
title = {Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients.},
volume = {35},
year = {2005}
}
TY - JOUR
ID - 837975
AU - Krejčí, Marta - Büchler, Tomáš - Hájek, Roman - Svobodník, A. - Křivanová, Andrea - Pour, Luděk - Adam, Zdeněk - Mayer, Jiří - Vorlíček, Jiří
PY - 2005
TI - Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients.
JF - Bone Marrow Transplantation
VL - 35
IS - 2
SP - 159-164
EP - 159-164
PB - Nature Publishing Group
SN - 02683369
KW - multiple myeloma
KW - autologous stem cell transplantation
N2 - Autologous stem cell transplantation (ASCT) has an established role in the treatment of symptomatic multiple myeloma (MM). Our aim was to analyse the impact of selected prognostic parameters on the survival of patients with MM after ASCT. The new International Staging System (ISS) was also evaluated. A total of 133 MM patients were transplanted in our centre between 1995 and 2002. Following ASCT, 35% of patients were in complete remission (CR) and 60% were in partial remission (PR). The median progression-free (PFS) and overall (OS) survival from transplantation were 29.5 and 68.8 months, respectively. Transplant-related mortality (TRM) was 3%. On multivariate analysis, factors associated with significantly shorter OS were lack of CR after transplant (P = 0.002, hazard ratio (HR): 3.1), stage 3 according to ISS (P = 0.001, HR: 3.0) and age at transplant over 60 years (P = 0.035, HR: 2.0). The status of disease before ASCT did not significantly affect PFS and OS after transplantation. We conclude that ASCT is a safe and effective procedure in MM patients, associated with low TRM. The survival after ASCT was dependent on response after ASCT, stage according to ISS and age.
ER -
KREJČÍ, Marta, Tomáš BÜCHLER, Roman HÁJEK, A. SVOBODNÍK, Andrea KŘIVANOVÁ, Luděk POUR, Zdeněk ADAM, Jiří MAYER a Jiří VORLÍČEK. Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients. \textit{Bone Marrow Transplantation}. London: Nature Publishing Group, 2005, roč.~35, č.~2, s.~159-164. ISSN~0268-3369.
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