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@misc{838030,
author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Labroli, Marc and Keertikar, Kartik},
keywords = {cyclin dependent kinase; cancer; inhibitor},
language = {eng},
title = {Novel pyrazolopyrimidines as novel cyćlin dependent kinase inhibitors},
year = {2008}
}
TY - PAT
ID - 838030
AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Labroli, Marc - Keertikar, Kartik
PY - 2008
TI - Novel pyrazolopyrimidines as novel cyćlin dependent kinase inhibitors
KW - cyclin dependent kinase
KW - cancer
KW - inhibitor
N2 - The title compds. [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I, alone or in combination with other therapeutic agent, is claimed.
ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI a Kartik KEERTIKAR. \textit{Novel pyrazolopyrimidines as novel cy\'clin dependent kinase inhibitors}. 2008. Patent. Číslo: WO 2008/130569 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 16. 4. 2008. Datum přijetí: 30. 10. 2008.
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