Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

P 2008

Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Ronald DOLL, Viyyoor GIRIJAVALLABHAN et. al.

Základní údaje

Originální název

Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Název česky

Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Autoři

Vydání

Číslo: US 2008/0050384 A1, Vydavatel: United States Patent Office, Místo vydání: USA, Název vlastníka: Schering Plough and Pharmacopeia, 2008

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

kinases; pyrazolopyrimidine; inhibitor

Klíčová slova anglicky

kinases; pyrazolopyrimidine; inhibitor

Štítky

inhibitor, kinases, pyrazolopyrimidine

Změněno: 23. 6. 2009 15:22, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

The title compds. [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compns. comprising the compd. I alone or in combination with other therapeutic agents are claimed.

Česky

viz Anotace

Citovat

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Ronald DOLL, Viyyoor GIRIJAVALLABHAN, Alan MALLAMS, Carmen ALVAREZ, Kartik KEERTIKAR, Jocelyn RIVERA, Tin-Yau CHAN, Vincent MADISON, Thierry FISCHMANN, Lawrence DILLARD, Vinh TRAN, Zhenmin HE, Ray JAMES, Haengsoon PARK, Vidyadhar PARADKAR, Douglas HOBBS, Paul KIRSCHMEIER a Rajat BANNERJI. Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors. 2008. Patent. Číslo: US 2008/0050384 A1. Vydavatel: United States Patent Office. Místo vydání: USA. Název vlastníka: Schering Plough and Pharmacopeia. Datum registrace: 20. 4. 2007. Datum přijetí: 28. 2. 2008.

@misc{838035,
   author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Doll, Ronald and Girijavallabhan, Viyyoor and Mallams, Alan and Alvarez, Carmen and Keertikar, Kartik and Rivera, Jocelyn and Chan, TinandYau and Madison, Vincent and Fischmann, Thierry and Dillard, Lawrence and Tran, Vinh and He, Zhenmin and James, Ray and Park, Haengsoon and Paradkar, Vidyadhar and Hobbs, Douglas and Kirschmeier, Paul and Bannerji, Rajat},
   keywords = {kinases; pyrazolopyrimidine; inhibitor},
   language = {eng},
   title = {Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors},
   year = {2008}
}

TY  - PAT
ID  - 838035
AU  - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Doll, Ronald - Girijavallabhan, Viyyoor - Mallams, Alan - Alvarez, Carmen - Keertikar, Kartik - Rivera, Jocelyn - Chan, Tin-Yau - Madison, Vincent - Fischmann, Thierry - Dillard, Lawrence - Tran, Vinh - He, Zhenmin - James, Ray - Park, Haengsoon - Paradkar, Vidyadhar - Hobbs, Douglas - Kirschmeier, Paul - Bannerji, Rajat
PY  - 2008
TI  - Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
KW  - kinases
KW  - pyrazolopyrimidine
KW  - inhibitor
N2  - The title compds. [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compns. comprising the compd. I alone or in combination with other therapeutic agents are claimed.
ER  -

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Ronald DOLL, Viyyoor GIRIJAVALLABHAN, Alan MALLAMS, Carmen ALVAREZ, Kartik KEERTIKAR, Jocelyn RIVERA, Tin-Yau CHAN, Vincent MADISON, Thierry FISCHMANN, Lawrence DILLARD, Vinh TRAN, Zhenmin HE, Ray JAMES, Haengsoon PARK, Vidyadhar PARADKAR, Douglas HOBBS, Paul KIRSCHMEIER a Rajat BANNERJI. \textit{Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}. 2008. Patent. Číslo: US 2008/0050384 A1. Vydavatel: United States Patent Office. Místo vydání: USA. Název vlastníka: Schering Plough and Pharmacopeia. Datum registrace: 20. 4. 2007. Datum přijetí: 28. 2. 2008.

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