Imidazopyrazines as protein kinase inhibitors

P 2007

Imidazopyrazines as protein kinase inhibitors

ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI et. al.

Základní údaje

Originální název

Imidazopyrazines as protein kinase inhibitors

Název česky

Imidazopyrazines as protein kinase inhibitors

Autoři

ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI a Arshad SIDDIQUI

Vydání

Číslo: WO 2007/145921 A1, Vydavatel: World Intellectual Property Organization, Místo vydání: USA, Název vlastníka: Schering-Plough, 2007

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

imidazopyrazines; kinase; inhibitor

Klíčová slova anglicky

imidazopyrazines; kinase; inhibitor

Štítky

imidazopyrazines, inhibitor, Kinase

Změněno: 23. 6. 2009 15:30, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

The invention provides a class of imidazopyrazine compds. of formula I as inhibitors of protein and/or checkpoint kinases, methods of prepg. such compds., pharmaceutical compns. including one or more such compds., methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. Compds. of formula I wherein R is H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted (hetero)cycloalkyl, etc.; R1 is H, (un)substituted alkyl, (un)substituted (hetero)aryl(alkyl), (un)substituted cycloalkenyl, etc.; R2 and R3 are independently H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, etc.; X is a covalent bond, CONH and derivs., SO2NH and derivs., NHCONH and derivs., CO2, OCO, OCONH and derivs., etc.; R4 is (un)substituted alkyl, (un)substituted CO2-alkyl, (un)substituted heterocyclyl, (un)substituted aryl and amine; and their pharmaceutically acceptable salts, solvates, esters and prodrugs thereof, are claimed. Example compd. II was prepd. by a multistep procedure (procedure given). All the invention compds. were evaluated for their protein kinase inhibitory activity (some data given).

Česky

viz Anotace

Citovat

ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI a Arshad SIDDIQUI. Imidazopyrazines as protein kinase inhibitors. 2007. Patent. Číslo: WO 2007/145921 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 5. 6. 2007. Datum přijetí: 21. 12. 2007.

@misc{838039,
   author = {Zhao, Lianyun and Reddy, Panduranga Adulla and Shih, NengandYang and Paruch, Kamil and Guzi, Timothy and Siddiqui, Arshad},
   keywords = {imidazopyrazines; kinase; inhibitor},
   language = {eng},
   title = {Imidazopyrazines as protein kinase inhibitors},
   year = {2007}
}

TY  - PAT
ID  - 838039
AU  - Zhao, Lianyun - Reddy, Panduranga Adulla - Shih, Neng-Yang - Paruch, Kamil - Guzi, Timothy - Siddiqui, Arshad
PY  - 2007
TI  - Imidazopyrazines as protein kinase inhibitors
KW  - imidazopyrazines
KW  - kinase
KW  - inhibitor
N2  - The invention provides a class of imidazopyrazine compds. of formula I as inhibitors of protein and/or checkpoint kinases, methods of prepg. such compds., pharmaceutical compns. including one or more such compds., methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. Compds. of formula I wherein R is H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted (hetero)cycloalkyl, etc.; R1 is H, (un)substituted alkyl, (un)substituted (hetero)aryl(alkyl), (un)substituted cycloalkenyl, etc.; R2 and R3 are independently H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, etc.; X is a covalent bond, CONH and derivs., SO2NH and derivs., NHCONH and derivs., CO2, OCO, OCONH and derivs., etc.; R4 is (un)substituted alkyl, (un)substituted CO2-alkyl, (un)substituted heterocyclyl, (un)substituted aryl and amine; and their pharmaceutically acceptable salts, solvates, esters and prodrugs thereof, are claimed. Example compd. II was prepd. by a multistep procedure (procedure given). All the invention compds. were evaluated for their protein kinase inhibitory activity (some data given).
ER  -

ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI a Arshad SIDDIQUI. \textit{Imidazopyrazines as protein kinase inhibitors}. 2007. Patent. Číslo: WO 2007/145921 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 5. 6. 2007. Datum přijetí: 21. 12. 2007.

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