Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

P 2004

Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

GUZI, Timothy; Kamil PARUCH; Michael DWYER; Ronald DOLL; Viyyoor GIRIJAVALLABHAN et al.

Základní údaje

Originální název

Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

Název česky

Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

Autoři

Vydání

Číslo: US 2004/209878 A1, Vydavatel: United States Patent and Trademark Office, Místo vydání: USA, Název vlastníka: Schering-Plough, 2004

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/04:00035987

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

cyclin dependent kinase; inhibitor; pyrazolopyrimidine

Klíčová slova anglicky

cyclin dependent kinase; inhibitor; pyrazolopyrimidine

Štítky

Cyclin dependent kinase, inhibitor, pyrazolopyrimidine

Změněno: 25. 6. 2009 15:09, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.

Česky

viz Anotace

Citovat

GUZI, Timothy; Kamil PARUCH; Michael DWYER; Ronald DOLL; Viyyoor GIRIJAVALLABHAN; Alan MALLAMS; Carmen ALVAREZ; Kartik KEERTIKAR; Jocelyn RIVERA; Tin-Yau CHAN; Vincent MADISON; Thierry FISCHMANN; Lawrence DILLARD; Vinh TRAN; Min ZHEN; Ray JAMES; Haengsoon PARK; Vidyadhar PARADKAR a Douglas HOBBS. Pyrazolopyrimidines as cyclin-dependent kinase inhibitors. 2004. Patent. Číslo: US 2004/209878 A1. Vydavatel: United States Patent and Trademark Office. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 11. 2. 2004. Datum přijetí: 21. 10. 2004.

@misc{838374,
   author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Doll, Ronald and Girijavallabhan, Viyyoor and Mallams, Alan and Alvarez, Carmen and Keertikar, Kartik and Rivera, Jocelyn and Chan, TinandYau and Madison, Vincent and Fischmann, Thierry and Dillard, Lawrence and Tran, Vinh and Zhen, Min and James, Ray and Park, Haengsoon and Paradkar, Vidyadhar and Hobbs, Douglas},
   keywords = {cyclin dependent kinase; inhibitor; pyrazolopyrimidine},
   language = {eng},
   title = {Pyrazolopyrimidines as cyclin-dependent kinase inhibitors},
   year = {2004}
}

TY  - PAT
ID  - 838374
AU  - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Doll, Ronald - Girijavallabhan, Viyyoor - Mallams, Alan - Alvarez, Carmen - Keertikar, Kartik - Rivera, Jocelyn - Chan, Tin-Yau - Madison, Vincent - Fischmann, Thierry - Dillard, Lawrence - Tran, Vinh - Zhen, Min - James, Ray - Park, Haengsoon - Paradkar, Vidyadhar - Hobbs, Douglas
PY  - 2004
TI  - Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
KW  - cyclin dependent kinase
KW  - inhibitor
KW  - pyrazolopyrimidine
N2  - The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.
ER  -

GUZI, Timothy; Kamil PARUCH; Michael DWYER; Ronald DOLL; Viyyoor GIRIJAVALLABHAN; Alan MALLAMS; Carmen ALVAREZ; Kartik KEERTIKAR; Jocelyn RIVERA; Tin-Yau CHAN; Vincent MADISON; Thierry FISCHMANN; Lawrence DILLARD; Vinh TRAN; Min ZHEN; Ray JAMES; Haengsoon PARK; Vidyadhar PARADKAR a Douglas HOBBS. \textit{Pyrazolopyrimidines as cyclin-dependent kinase inhibitors}. 2004. Patent. Číslo: US 2004/209878 A1. Vydavatel: United States Patent and Trademark Office. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 11. 2. 2004. Datum přijetí: 21. 10. 2004.

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