Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

P 2004

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

GUZI, Timothy; Kamil PARUCH; Michael DWYER; Ronald DOLL; Viyyoor GIRIJAVALLABHAN et al.

Základní údaje

Originální název

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

Název česky

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

Autoři

GUZI, Timothy; Kamil PARUCH; Michael DWYER; Ronald DOLL; Viyyoor GIRIJAVALLABHAN; Lawrence DILLARD; Vinh TRAN; Zhe HE; Ray JAMES a Haengsoon PARK

Vydání

Číslo: WO 2004/022560 A1, Vydavatel: World Intellectual Property Organization, Místo vydání: USA, Název vlastníka: Schering-Plough; Pharmacopeia, 2004

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

10401 Organic chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/04:00036001

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

cyclin dependent kinase; inhibitor; pyrazolopyrimidine

Klíčová slova anglicky

cyclin dependent kinase; inhibitor; pyrazolopyrimidine

Štítky

Cyclin dependent kinase, inhibitor, pyrazolopyrimidine

Změněno: 25. 6. 2009 10:38, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

The title pyrazolo[1,5-a]pyrimidines [I; Q = SO2, CO; R = each (un)substituted aryl or heteroaryl; R2 = cyano, NR5R6, CO2R6, CONR5R6, OR6, SR6, SO2R7, SO2NR5R6, -N(R5)SO2R7, N(R5)COR7, N(R5)CONR5R6, alkynyl, heteroaryl, CF3, heterocyclyl, alkynylalkyl, cycloalkyl, (un)substituted alkyl; R3 = H, halogen, NR5R6, CONR5R6, each (un)substituted alkyl, alkynyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, etc.; R4 = H, halo, alkyl; R5 = H, alkyl; R6 = H, each (un)substituted alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; or R5 and R6 in the moiety -NR5R6, may be joined together to form an (un)substituted cycloalkyl or heterocyclyl] or pharmaceutically acceptable salts or solvates thereof are prepd. In its many embodiments, the present invention also provides methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds. I, methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with cyclin dependent kinase using such compds. I or pharmaceutical compns. The disease assocd. with cyclin dependent kinase is selected from the group consisting of; (1) cancer of the bladder, breast, colon, kidney, liver, lung, small cell lung cancer, esophagus, gall bladder, ovary, pancreas, stomach, cervix, thyroid, prostate, and skin, including squamous cell carcinoma; (2) leukemia, acute lymphocytic leukemia, acute lymphoblastic leukemia, B-cell lymphoma, T-cell lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, hairy cell lymphoma and Burkitt's lymphoma; (3) acute and chronic myelogenous leukemia, myelodysplastic syndrome and promyelocytic leukemia; (4) fibrosarcoma and rhabdomyosarcoma; (5) astrocytoma, neuroblastoma, glioma and schwannomas; and (6) melanoma, seminoma, teratocarcinoma, osteosarcoma, xeroderma pigmentosum, keratoacanthoma, thyroid follicular cancer and Kaposi's sarcoma.

Česky

viz Anotace

Citovat

GUZI, Timothy; Kamil PARUCH; Michael DWYER; Ronald DOLL; Viyyoor GIRIJAVALLABHAN; Lawrence DILLARD; Vinh TRAN; Zhe HE; Ray JAMES a Haengsoon PARK. Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors. 2004. Patent. Číslo: WO 2004/022560 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough; Pharmacopeia. Datum registrace: 3. 9. 2003. Datum přijetí: 18. 3. 2004.

@misc{838409,
   author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Doll, Ronald and Girijavallabhan, Viyyoor and Dillard, Lawrence and Tran, Vinh and He, Zhe and James, Ray and Park, Haengsoon},
   keywords = {cyclin dependent kinase; inhibitor; pyrazolopyrimidine},
   language = {eng},
   title = {Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors},
   year = {2004}
}

TY  - PAT
ID  - 838409
AU  - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Doll, Ronald - Girijavallabhan, Viyyoor - Dillard, Lawrence - Tran, Vinh - He, Zhe - James, Ray - Park, Haengsoon
PY  - 2004
TI  - Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
KW  - cyclin dependent kinase
KW  - inhibitor
KW  - pyrazolopyrimidine
N2  - The title pyrazolo[1,5-a]pyrimidines [I; Q = SO2, CO; R = each (un)substituted aryl or heteroaryl; R2 = cyano, NR5R6, CO2R6, CONR5R6, OR6, SR6, SO2R7, SO2NR5R6, -N(R5)SO2R7, N(R5)COR7, N(R5)CONR5R6, alkynyl, heteroaryl, CF3, heterocyclyl, alkynylalkyl, cycloalkyl, (un)substituted alkyl; R3 = H, halogen, NR5R6, CONR5R6, each (un)substituted alkyl, alkynyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, etc.; R4 = H, halo, alkyl; R5 = H, alkyl; R6 = H, each (un)substituted alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; or R5 and R6 in the moiety -NR5R6, may be joined together to form an (un)substituted cycloalkyl or heterocyclyl] or pharmaceutically acceptable salts or solvates thereof are prepd. In its many embodiments, the present invention also provides methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds. I, methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with cyclin dependent kinase using such compds. I or pharmaceutical compns. The disease assocd. with cyclin dependent kinase is selected from the group consisting of; (1) cancer of the bladder, breast, colon, kidney, liver, lung, small cell lung cancer, esophagus, gall bladder, ovary, pancreas, stomach, cervix, thyroid, prostate, and skin, including squamous cell carcinoma; (2) leukemia, acute lymphocytic leukemia, acute lymphoblastic leukemia, B-cell lymphoma, T-cell lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, hairy cell lymphoma and Burkitt's lymphoma; (3) acute and chronic myelogenous leukemia, myelodysplastic syndrome and promyelocytic leukemia; (4) fibrosarcoma and rhabdomyosarcoma; (5) astrocytoma, neuroblastoma, glioma and schwannomas; and (6) melanoma, seminoma, teratocarcinoma, osteosarcoma, xeroderma pigmentosum, keratoacanthoma, thyroid follicular cancer and Kaposi's sarcoma.
ER  -

GUZI, Timothy; Kamil PARUCH; Michael DWYER; Ronald DOLL; Viyyoor GIRIJAVALLABHAN; Lawrence DILLARD; Vinh TRAN; Zhe HE; Ray JAMES a Haengsoon PARK. \textit{Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors}. 2004. Patent. Číslo: WO 2004/022560 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough; Pharmacopeia. Datum registrace: 3. 9. 2003. Datum přijetí: 18. 3. 2004.

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