| BRÁZDA, Václav, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ, Zuzana VESELKOVÁ a Petr DUBOVÝ. Bilateral changes in IL-6 protein, but not in its receptor gp130, in rat dorsal root ganglia following sciatic nerve ligature. Cellular and Molecular Neurobiology. 2009, roč. 29, 6-7, s. 1053-62, 10 s. ISSN 0272-4340. |
Další formáty:
BibTeX
LaTeX
RIS
@article{838420,
author = {Brázda, Václav and Klusáková, Ilona and Svíženská, Ivana and Veselková, Zuzana and Dubový, Petr},
article_number = {6-7},
keywords = {Unilateral nerve injury - Neuropathic pain - IL-6 signaling},
language = {eng},
issn = {0272-4340},
journal = {Cellular and Molecular Neurobiology},
title = {Bilateral changes in IL-6 protein, but not in its receptor gp130, in rat dorsal root ganglia following sciatic nerve ligature},
volume = {29},
year = {2009}
}
TY - JOUR
ID - 838420
AU - Brázda, Václav - Klusáková, Ilona - Svíženská, Ivana - Veselková, Zuzana - Dubový, Petr
PY - 2009
TI - Bilateral changes in IL-6 protein, but not in its receptor gp130, in rat dorsal root ganglia following sciatic nerve ligature
JF - Cellular and Molecular Neurobiology
VL - 29
IS - 6-7
SP - 1053-62
EP - 1053-62
SN - 02724340
KW - Unilateral nerve injury - Neuropathic pain - IL-6 signaling
N2 - Rats were operated aseptically on unilateral ScNL and allowed to survive for 1, 3, 7, and 14 days. Immunohistochemistry and Western blot analysis were used to determine levels of IL-6 and gp130 in DRG. A distinct increase in immunostaining for IL-6 was found in the neuronal cell bodies of sections through both ipsilateral and contralateral DRG at 1 and 3 days after operation. The levels of IL-6 protein increased in both ipsilateral and contralateral lumbal DRG following peripheral nerve injury. The elevation of IL-6 protein was significant in both ipsilateral and contralateral DRG 1, 3, 7, and 14 days after operation, the levels of gp130 receptor did not change significantly. The data provide evidence for changes in IL-6 levels not only in the DRG associated with the damaged nerve but also in those unassociated with nerve injury during the experimental neuropathic pain model.
ER -
BRÁZDA, Václav, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ, Zuzana VESELKOVÁ a Petr DUBOVÝ. Bilateral changes in IL-6 protein, but not in its receptor gp130, in rat dorsal root ganglia following sciatic nerve ligature. \textit{Cellular and Molecular Neurobiology}. 2009, roč.~29, 6-7, s.~1053-62, 10 s. ISSN~0272-4340.
|
