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@misc{838520, author = {Guzi, Timothy and Paruch, Kamil}, keywords = {hydroxysteroid dehydrogenase; inhibitor; prostate cancer}, language = {eng}, title = {Piperidine- and Piperazineacetamides as 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors for the Treatment of Androgen Dependent Diseases}, year = {2003} }
TY - PAT ID - 838520 AU - Guzi, Timothy - Paruch, Kamil PY - 2003 TI - Piperidine- and Piperazineacetamides as 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors for the Treatment of Androgen Dependent Diseases KW - hydroxysteroid dehydrogenase KW - inhibitor KW - prostate cancer N2 - Compds. of formula I [R1 = aryl, heteroaryl, arylalkyl, heteroarylalkyl, diphenylalkyl, etc.; R2, R3 = H, OH, alkoxy, alkyl, cycloalkyl, etc.; R4, R5, R7, R8 = H, substituted OH, substituted amino, alkyl, aryl, cycloalkyl, etc.; R6 = acyl, substituted sulfonyl; R9, R10 = H, F, CF3, alkyl, cycloalkyl, arylalkyl, etc.; X, Z = C, N] are prepd. which are useful as inhibitors of Type 3 17.beta.-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compns. contg. said compds. and their use for the treatment or prevention of androgen dependent diseases. Thus, II was prepd. in several steps. The prepd. compds. had type 3 17.beta.-hydroxysteroid dehydrogenase binding activity of 0.010 to 100 nM. ER -
GUZI, Timothy a Kamil PARUCH. \textit{Piperidine- and Piperazineacetamides as 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors for the Treatment of Androgen Dependent Diseases}. 2003. Patent. Číslo: WO 2003/33487 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 15. 10. 2002. Datum přijetí: 24. 4. 2003.
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