VAŇÁČOVÁ, Štěpánka, D.R. LISTON, Jan TACHEZY and Patricia J. JOHNSON. Molecular biology of the amitochondriate parasites, Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. International Journal for Parasitology. Elsevier Science, 2003, vol. 33, No 3, p. 235-255, 20 pp. ISSN 0020-7519.
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Basic information
Original name Molecular biology of the amitochondriate parasites, Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis.
Name in Czech Molecular biology of the amitochondriate parasites, Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis.
Authors VAŇÁČOVÁ, Štěpánka (203 Czech Republic, guarantor), D.R. LISTON (840 United States of America), Jan TACHEZY (203 Czech Republic) and Patricia J. JOHNSON (840 United States of America).
Edition International Journal for Parasitology, Elsevier Science, 2003, 0020-7519.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.881
RIV identification code RIV/00216224:14310/03:00036239
Organization unit Faculty of Science
UT WoS 000182359100002
Keywords (in Czech) Trichomonas; Giardia; Entamoeba; amitochondriate; mitochondria; gene expression; genome
Keywords in English Trichomonas; Giardia; Entamoeba; amitochondriate; mitochondria; gene expression; genome
Tags amitochondriate, Entamoeba, GENE EXPRESSION, genome, Giardia, mitochondria, Trichomonas
Tags International impact, Reviewed
Changed by Changed by: prof. Mgr. Štěpánka Vaňáčová, Ph.D., učo 105562. Changed: 29/3/2010 16:10.
Abstract
The amitochondriates are an assembly of unicellular protists that lack mitochondria, and often other typical eukaryotic organelles, such as peroxisomes. Relatively little research has been conducted on amitochondriates, even though marine waters are likely to be teeming with such organisms, representing yet unknown protist lineages. The three amitochondriates that have been studied in any detail are the three mucosal human parasites: Giardia, Trichomonas and Entamoeba. These pathogens have worldwide distribution and are the most commonly encountered parasites in North America and Europe. Despite significant differences in their lifecycles and pathogenic properties, Giardia, Trichomonas and Entamoeba are customarily grouped together based on their being microaerophilic, their anaerobic carbohydrate metabolism, their lack of mitochondria, and their placement on deep-branching lineages in eukaryotic phylogenetic trees. During the last decade, the development of functional tools has allowed molecular analyses of gene expression to be initiated on these divergent eukaryotes. The resulting data indicate significant differences between the organisation of genetic information and mechanisms of gene regulation in amitochondriates and other organisms. Promoter architecture, as well as the regulatory transcription factors required to mediate promoter activity, lacks the conservation observed for the transcriptional apparatuses of metazoa and even appear to be unique within the amitochondriates. Our knowledge of the molecular biology and gene expression in amitochondriates is still in its infancy and a discussion of the current status of research in this area is presented.
Abstract (in Czech)
The amitochondriates are an assembly of unicellular protists that lack mitochondria, and often other typical eukaryotic organelles, such as peroxisomes. Relatively little research has been conducted on amitochondriates, even though marine waters are likely to be teeming with such organisms, representing yet unknown protist lineages. The three amitochondriates that have been studied in any detail are the three mucosal human parasites: Giardia, Trichomonas and Entamoeba. These pathogens have worldwide distribution and are the most commonly encountered parasites in North America and Europe. Despite significant differences in their lifecycles and pathogenic properties, Giardia, Trichomonas and Entamoeba are customarily grouped together based on their being microaerophilic, their anaerobic carbohydrate metabolism, their lack of mitochondria, and their placement on deep-branching lineages in eukaryotic phylogenetic trees. During the last decade, the development of functional tools has allowed molecular analyses of gene expression to be initiated on these divergent eukaryotes. The resulting data indicate significant differences between the organisation of genetic information and mechanisms of gene regulation in amitochondriates and other organisms. Promoter architecture, as well as the regulatory transcription factors required to mediate promoter activity, lacks the conservation observed for the transcriptional apparatuses of metazoa and even appear to be unique within the amitochondriates. Our knowledge of the molecular biology and gene expression in amitochondriates is still in its infancy and a discussion of the current status of research in this area is presented.
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