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@article{845544,
author = {Bienertová Vašků, Julie and Bienert, Petr and Tomandl, Josef and Forejt, Martin and Derflerová Brázdová, Zuzana and Vašků, Anna},
article_location = {Cambridge},
article_number = {14},
keywords = {Adipokine; polymorphism; obesity; dietary composition},
language = {eng},
issn = {0007-1145},
journal = {British Journal of Nutrition},
title = {Genotype 3 nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake},
volume = {2009},
year = {2009}
}
TY - JOUR
ID - 845544
AU - Bienertová Vašků, Julie - Bienert, Petr - Tomandl, Josef - Forejt, Martin - Derflerová Brázdová, Zuzana - Vašků, Anna
PY - 2009
TI - Genotype 3 nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake
JF - British Journal of Nutrition
VL - 2009
IS - 14
SP - 1-8
EP - 1-8
PB - Cambridge University Press
SN - 00071145
KW - Adipokine
KW - polymorphism
KW - obesity
KW - dietary composition
N2 - Individual dietary composition can either enhance or suppress the development of obesity and the selection and proportion of macronutrients in the diet seems to have a heritable component. In this study, we focused on dietary composition as the typical obesity-related trait and we investigated selected genetic variations in leptin (LEP), leptin receptor (LEPR), adiponectin (ADIPOQ), interleukin 6 (IL6) and proopiomelanocortin (POMC). The total of 409 individuals of Czech Caucasian origin were enrolled into this study and the 7-day food records were obtained from the study subjects along with selected anthropometric measurements. The LEP +19A/G polymorphism served as an independent predictor for BMI, % of body fat and skin fold thickness and significantly affected the time structure of the daily energy intake. The POMC RsaI polymorphism was associated with the % of body fat. ADIPOQ 45 T/G polymorphism was associated with the thickness of the subscapular skin fold. The LEPR Gln223Arg polymorphism was associated with multiple parameters, including diastolic blood pressure, meal sizes during the day and plasma adiponectin levels. In a separate analysis, sObR plasma levels and leptin/sObR ratio were significantly correlated with systolic blood pressure (beta = -0.66, p = 0.002; resp. beta = -1.23, p = 0.02) and sObR plasma levels also served as an independent predictor for diastolic blood pressure (beta = -0.50, p = 0.04). To conclude, we report common allelic variants associated with specific feeding behaviour and obesity-related anthropometric traits. Moreover, we identified allelic variants that significantly influence time structure of food intake.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Zuzana DERFLEROVÁ BRÁZDOVÁ a Anna VAŠKŮ. Genotype 3 nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. \textit{British Journal of Nutrition}. Cambridge: Cambridge University Press, 2009, roč.~2009, č.~14, s.~1-8. ISSN~0007-1145.
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