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@proceedings{855835,
author = {Kovářová, Lucie and Burešová, Ivana and Suská, Renata and Muthu Raja, Karthick Raja and Perutka, Tomáš and Zarbochová, Pavla and Penka, Miroslav and Hájek, Roman},
booktitle = {4th MYELOMA and 2nd IMMUNOTHERAPY WORKSHOP},
keywords = {flow cytometry; plasma cells; phenotype; multiple myeloma; monoclonal gammopathy},
language = {eng},
isbn = {978-80-210-4977-2},
title = {Comparison of plasma cells phenotype in MGUS and MM},
year = {2009}
}
TY - CONF
ID - 855835
AU - Kovářová, Lucie - Burešová, Ivana - Suská, Renata - Muthu Raja, Karthick Raja - Perutka, Tomáš - Zarbochová, Pavla - Penka, Miroslav - Hájek, Roman
PY - 2009
TI - Comparison of plasma cells phenotype in MGUS and MM
SN - 9788021049772
KW - flow cytometry
KW - plasma cells
KW - phenotype
KW - multiple myeloma
KW - monoclonal gammopathy
N2 - Flow cytometric (FC) analysis of monoclonal gammopathies is not routinely used for establishing of the diagnosis in multiple myeloma (MM) and/or monoclonal gammopathy of undetermined significance (MGUS). Markers associated with myelomatous plasma cells (PCs) are mostly known, but only limited information about their relation to prognosis is available. As MGUS pass into MM by multistep transformation process, we try to compare phenotype patterns of these diseases to find parameter with a predictive value in the term of disease progression. Flow cytometric analysis of PC phenotype was done in 112 newly diagnosed patients with MM and 31 MGUS subjects. Bone marrow PCs were identified as CD38+CD138+ cells and expression of CD19, CD20, CD27, CD28, CD56 and CD117 was analysed on these PCs in 5-colors setting. Flow cytometry is a sensitive technique which allows detection of a few PCs in MGUS and MM cases, however phenotypic characterization and discrimination of normal and malignant PCs should be more important then their number. Higher number of CD19+ normal PCs correlate with MGUS as higher number of CD56+ myelomatous PCs correlate with MM. CD27 seems to have a predictive value for progression of disease and should be monitored for its possible prognostic information as well.
ER -
KOVÁŘOVÁ, Lucie, Ivana BUREŠOVÁ, Renata SUSKÁ, Karthick Raja MUTHU RAJA, Tomáš PERUTKA, Pavla ZARBOCHOVÁ, Miroslav PENKA a Roman HÁJEK. Comparison of plasma cells phenotype in MGUS and MM. In \textit{4th MYELOMA and 2nd IMMUNOTHERAPY WORKSHOP}. ISBN~978-80-210-4977-2. 2009.
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