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@article{856227,
author = {Adam, Zdeněk and Pour, Luděk and Krejčí, Marta and Neubauer, Jiří and Prášek, Jiří and Büchler, Tomáš and Hájek, Roman},
article_number = {4},
keywords = {Schnitzler Syndrome; Gammapathy;Urticaria; Anakinra},
language = {eng},
issn = {1543-9135},
journal = {Cancer Therapy},
title = {Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens},
volume = {7},
year = {2009}
}
TY - JOUR
ID - 856227
AU - Adam, Zdeněk - Pour, Luděk - Krejčí, Marta - Neubauer, Jiří - Prášek, Jiří - Büchler, Tomáš - Hájek, Roman
PY - 2009
TI - Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens
JF - Cancer Therapy
VL - 7
IS - 4
SN - 15439135
KW - Schnitzler Syndrome
KW - Gammapathy;Urticaria
KW - Anakinra
N2 - Schnitzler syndrome is a rare disorder characterized by chronic urticaria, the presence of monoclonal class IgM immunoglobulin, lymphadenopathy and fevers. We report on a patient who was diagnosed in 1996 and over the next 12 years underwent a number of therapies. Bone pain associated with proven osteolytic and osteosclerotic lesions resolved on regular bisphosphonate treatment with pamidronate and, later, clodronate. The patient had transient benefit from treatments with interferon-alpha and with PUVA. No therapeutic effects were seen with high-dose dexamethasone, 2-chlordeoxyadenosin, cyclosporine, or the combination of bortezomib, thalidomide, and dexamethasone. However, on therapy with anakinra the patients skin symptoms resolved completely and the values of CRP and hemoglobin normalized.
ER -
ADAM, Zdeněk, Luděk POUR, Marta KREJČÍ, Jiří NEUBAUER, Jiří PRÁŠEK, Tomáš BÜCHLER a Roman HÁJEK. Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens. \textit{Cancer Therapy}. 2009, roč.~7, č.~4, 6 s. ISSN~1543-9135.
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