MAMEDOV, Ilgar, Petr TÁBORSKÝ, Přemysl LUBAL, Sophie LAURENT, Luc VANDER ELST, Hermann A. MAYER, Nikos LOGOTHETIS a Goran ANGELOVSKI. Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates. Eur. J. Inorg. Chem. Germany: Wiley-VCH Verlag GMBH, 2009, roč. 2009, č. 22, s. 3298 - 3306. ISSN 1434-1948. |
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@article{857790, author = {Mamedov, Ilgar and Táborský, Petr and Lubal, Přemysl and Laurent, Sophie and Vander Elst, Luc and Mayer, Hermann A. and Logothetis, Nikos and Angelovski, Goran}, article_location = {Germany}, article_number = {22}, keywords = {Lanthanides; phosphonates; kinetics; termodynamics; contrast agents}, language = {eng}, issn = {1434-1948}, journal = {Eur. J. Inorg. Chem.}, title = {Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates}, url = {http://www3.interscience.wiley.com/journal/122464962/abstract}, volume = {2009}, year = {2009} }
TY - JOUR ID - 857790 AU - Mamedov, Ilgar - Táborský, Petr - Lubal, Přemysl - Laurent, Sophie - Vander Elst, Luc - Mayer, Hermann A. - Logothetis, Nikos - Angelovski, Goran PY - 2009 TI - Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates JF - Eur. J. Inorg. Chem. VL - 2009 IS - 22 SP - 3298 - 3306 EP - 3298 - 3306 PB - Wiley-VCH Verlag GMBH SN - 14341948 KW - Lanthanides KW - phosphonates KW - kinetics KW - termodynamics KW - contrast agents UR - http://www3.interscience.wiley.com/journal/122464962/abstract N2 - Two DO3A-based ligands appended with the propylphosphonate side arm and their Ln3+ complexes were investigated. Proton relaxometric in vitro studies at 20 MHz and 60 MHz and 37 degree of Celsius of the Gd3+ complex containing free acid exhibited relative changes of up to 56 % in r1 relaxivity when the pH of the medium was changed from 4 to 7. This change is explained by the decrease in the number of coordinated water molecules from two to one. Temperature-dependent relaxivity and NMRD profiles of Gd3+ complexes showed a fast water exchange and a slightly increased rotational correlation time, which is characteristic of phosphonate-containing compounds. Thermodynamic and kinetic studies of the Gd3+ and Eu3+ complexes were performed by means of potentiometry and luminescence spectroscopy. The results indicate that the thermodynamic stability and kinetic inertness of these complexes are sufficient for their in vivo application. ER -
MAMEDOV, Ilgar, Petr TÁBORSKÝ, Přemysl LUBAL, Sophie LAURENT, Luc VANDER ELST, Hermann A. MAYER, Nikos LOGOTHETIS a Goran ANGELOVSKI. Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates. \textit{Eur. J. Inorg. Chem.}. Germany: Wiley-VCH Verlag GMBH, 2009, roč.~2009, č.~22, s.~3298 - 3306. ISSN~1434-1948.
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