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@article{858785,
author = {Harničarová, Andrea and Bártová, Eva and Galiová, Gabriela and Uhlířová, Radka and Matula, Pavel and Kozubek, Stanislav},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s00412-009-0252-2},
keywords = {SUV39h; heterochromatin protein 1; nucleoli; cell nucleus},
language = {eng},
issn = {0009-5915},
journal = {Chromosoma},
title = {SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions},
url = {http://www.springerlink.com/content/03353h53h300j70k/},
volume = {119},
year = {2010}
}
TY - JOUR
ID - 858785
AU - Harničarová, Andrea - Bártová, Eva - Galiová, Gabriela - Uhlířová, Radka - Matula, Pavel - Kozubek, Stanislav
PY - 2010
TI - SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions
JF - Chromosoma
VL - 119
IS - 3
SP - 227-241
EP - 227-241
PB - Springer
SN - 00095915
KW - SUV39h
KW - heterochromatin protein 1
KW - nucleoli
KW - cell nucleus
UR - http://www.springerlink.com/content/03353h53h300j70k/
L2 - http://www.springerlink.com/content/03353h53h300j70k/
N2 - Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin. We observed that HP1beta is located in both the chromocenters and fibrillarin-positive nucleoli interiors. However, HP1alfa and HP1gamma occupied fibrillarin-positive compartments to a lesser extent, corresponding to the distinct levels of HP1 subtypes at the promoter of rDNA genes. Deficiency of histone methyltransferases SUV39h, and/or inhibition of histone deacetylases (HDACi) decreased HP1beta and H3K9 trimethylation at chromocenters, but not in fibrillarin-positive regions that co-localized with RNA Pol I. Similarly, SUV39h- and HDACi-dependent nucleolar rearrangement and inhibition of rDNA transcription did not affect the association between HP1beta - and fibrillarin. The presence of HP1beta in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleolar processes.
ER -
HARNIČAROVÁ, Andrea, Eva BÁRTOVÁ, Gabriela GALIOVÁ, Radka UHLÍŘOVÁ, Pavel MATULA a Stanislav KOZUBEK. SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions. \textit{Chromosoma}. Springer, 2010, roč.~119, č.~3, s.~227-241. ISSN~0009-5915. Dostupné z: https://dx.doi.org/10.1007/s00412-009-0252-2.
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