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@proceedings{858921,
author = {Lubal, Přemysl and Svobodová, Ivona and Pasulka, Josef and Hermann, Petr},
booktitle = {COST D38 Annual Workshop},
keywords = {Macrocyclic ligands; Cu(III) complexes; radioisotope diagnostics and therapy; thermodynamics; kinetics},
language = {eng},
title = {Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives},
year = {2009}
}
TY - CONF
ID - 858921
AU - Lubal, Přemysl - Svobodová, Ivona - Pasulka, Josef - Hermann, Petr
PY - 2009
TI - Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives
KW - Macrocyclic ligands
KW - Cu(III) complexes
KW - radioisotope diagnostics and therapy
KW - thermodynamics
KW - kinetics
N2 - Bifunctional chelating agents (BFC) complexing copper(II) ion are utilized in nuclear medicine, e.g. in radioisotope diagnostics (64Cu) or in tumor radiotherapy (67Cu). BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Therefore, it is necessary to know thermodynamic and kinetic properties (dissociation rate constants for estimation of kinetic inertness) of copper(II) complexes in order to find the best macrocyclic BFC for possible medical applications in vivo. In this work, the thermodynamic and kinetic properties of copper(II) complexes with macrocyclic ligands with acetic and phosphorus acid pendant arms were studied.
ER -
LUBAL, Přemysl, Ivona SVOBODOVÁ, Josef PASULKA a Petr HERMANN. Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives. In \textit{COST D38 Annual Workshop}. 2009.
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