Status of minimal residual disease determines outcome of
autologous hematopoietic SCT in adult ALL

J 2010

Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL

GIEBEL, S., B. STELLA-HOLOWIECKA, M. KRAWCZYK-KULIS, N. GÖKBUGET, D. HOELZER et. al.

Základní údaje

Originální název

Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL

Autoři

GIEBEL, S. (616 Polsko, garant), B. STELLA-HOLOWIECKA (616 Polsko), M. KRAWCZYK-KULIS (616 Polsko), N. GÖKBUGET (276 Německo), D. HOELZER (276 Německo), Michael DOUBEK (203 Česká republika, domácí), Jiří MAYER (203 Česká republika, domácí), B. PIATKOWSKA-JAKUBAS (616 Polsko), A.B. SKOTNICKI (616 Polsko), H. DOMBRET (250 Francie), J.M. RIBERA (724 Španělsko), P.P. PICCALUGA (380 Itálie), T. CZERW (616 Polsko), S. KYRCZ-KRZEMIEN (616 Polsko) a J. HOLOWIECKI (616 Polsko)

Vydání

Bone Marrow Transplantation, 2010, 0268-3369

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.660

Kód RIV

RIV/00216224:14110/10:00051241

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/bmt.2009.308

UT WoS

000278573600021

Klíčová slova anglicky

auto transplant; ALL; minimal residual disease

Příznaky

Mezinárodní význam

Změněno: 20. 4. 2012 11:05, Mgr. Michal Petr

Anotace

V originále

The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL. Our results suggest the need to reevaluate the role of this treatment option in prospective trials.

Citovat

GIEBEL, S., B. STELLA-HOLOWIECKA, M. KRAWCZYK-KULIS, N. GÖKBUGET, D. HOELZER, Michael DOUBEK, Jiří MAYER, B. PIATKOWSKA-JAKUBAS, A.B. SKOTNICKI, H. DOMBRET, J.M. RIBERA, P.P. PICCALUGA, T. CZERW, S. KYRCZ-KRZEMIEN a J. HOLOWIECKI. Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL. Bone Marrow Transplantation. 2010, roč. 45, č. 6, s. 1095-1101. ISSN 0268-3369. Dostupné z: https://dx.doi.org/10.1038/bmt.2009.308.

@article{859796,
   author = {Giebel, S. and StellaandHolowiecka, B. and KrawczykandKulis, M. and Gökbuget, N. and Hoelzer, D. and Doubek, Michael and Mayer, Jiří and PiatkowskaandJakubas, B. and Skotnicki, A.B. and Dombret, H. and Ribera, J.M. and Piccaluga, P.P. and Czerw, T. and KyrczandKrzemien, S. and Holowiecki, J.},
   article_number = {6},
   doi = {http://dx.doi.org/10.1038/bmt.2009.308},
   keywords = {auto transplant; ALL; minimal residual disease},
   language = {eng},
   issn = {0268-3369},
   journal = {Bone Marrow Transplantation},
   title = {Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL},
   volume = {45},
   year = {2010}
}

TY  - JOUR
ID  - 859796
AU  - Giebel, S. - Stella-Holowiecka, B. - Krawczyk-Kulis, M. - Gökbuget, N. - Hoelzer, D. - Doubek, Michael - Mayer, Jiří - Piatkowska-Jakubas, B. - Skotnicki, A.B. - Dombret, H. - Ribera, J.M. - Piccaluga, P.P. - Czerw, T. - Kyrcz-Krzemien, S. - Holowiecki, J.
PY  - 2010
TI  - Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL
JF  - Bone Marrow Transplantation
VL  - 45
IS  - 6
SP  - 1095-1101
EP  - 1095-1101
SN  - 02683369
KW  - auto transplant
KW  - ALL
KW  - minimal residual disease
N2  - The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL. Our results suggest the need to reevaluate the role of this treatment option in prospective trials.
ER  -

GIEBEL, S., B. STELLA-HOLOWIECKA, M. KRAWCZYK-KULIS, N. GÖKBUGET, D. HOELZER, Michael DOUBEK, Jiří MAYER, B. PIATKOWSKA-JAKUBAS, A.B. SKOTNICKI, H. DOMBRET, J.M. RIBERA, P.P. PICCALUGA, T. CZERW, S. KYRCZ-KRZEMIEN a J. HOLOWIECKI. Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL. \textit{Bone Marrow Transplantation}. 2010, roč.~45, č.~6, s.~1095-1101. ISSN~0268-3369. Dostupné z: https://dx.doi.org/10.1038/bmt.2009.308.

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