The role of mammalian cardiac t-tubules in
excitation-contraction coupling: experimental and computational
approaches

J 2009

The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches

ORCHARD, C.; Michal PÁSEK a F. BRETTE

Základní údaje

Originální název

The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches

Název česky

Role srdečních t-tubulů ve vazbě excitace-kontrakce u savců: experimentální a výpočtové přístupy

Autoři

ORCHARD, C.; Michal PÁSEK a F. BRETTE

Vydání

Experimental Physiology, Wiley-Blackwell Publishing, Inc, 2009, 0958-0670

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.168

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

UT WoS

000265186600005

Klíčová slova anglicky

cardiac cell; t-tubules; excitation-contraction coupling; mathematical modelling

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 5. 2011 21:53, doc. Ing. Michal Pásek, Ph.D.

Anotace

ORIG CZ

V originále

The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions.While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation-contraction coupling.

Česky

Buněčná membrána komorových kardiomyocytů obsahuje četné invaginace nazývané transverzální tubuly (t-tubuly). Práce shrnuje výsledky nejnovějších experimentálních a výpočtových studií ukazujících důležitost t-tubulů ve vazbě excitace-kontrakce u srdečních buněk.

Návaznosti

AV0Z20760514, záměr

Název: Komplexní dynamické systémy v termodynamice, mechanice tekutin a těles

Citovat

ORCHARD, C.; Michal PÁSEK a F. BRETTE. The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches. Experimental Physiology. Wiley-Blackwell Publishing, Inc, 2009, roč. 94, č. 5, s. 509-519. ISSN 0958-0670.

@article{861452,
   author = {Orchard, C. and Pásek, Michal and Brette, F.},
   article_number = {5},
   keywords = {cardiac cell; t-tubules; excitation-contraction coupling; mathematical modelling},
   language = {eng},
   issn = {0958-0670},
   journal = {Experimental Physiology},
   title = {The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches},
   volume = {94},
   year = {2009}
}

TY  - JOUR
ID  - 861452
AU  - Orchard, C. - Pásek, Michal - Brette, F.
PY  - 2009
TI  - The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches
JF  - Experimental Physiology
VL  - 94
IS  - 5
SP  - 509-519
EP  - 509-519
PB  - Wiley-Blackwell Publishing, Inc
SN  - 09580670
KW  - cardiac cell
KW  - t-tubules
KW  - excitation-contraction coupling
KW  - mathematical modelling
N2  - The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions.While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation-contraction coupling.
ER  -

ORCHARD, C.; Michal PÁSEK a F. BRETTE. The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches. \textit{Experimental Physiology}. Wiley-Blackwell Publishing, Inc, 2009, roč.~94, č.~5, s.~509-519. ISSN~0958-0670.

Přehled o publikaci