WANG, Zhi, Christine WILHELMSSON, Pavel HYRŠL, Torsten G. LOOF, Pavel DOBEŠ, Martina KLUPP, Olga LOSEVA, Matthias MÖRGELIN, Jennifer IKLÉ, Richard M. CRIPPS, Heiko HERWALD a Ulrich THEOPOLD. Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism. PLoS Pathogens, San Francisco: Public Library Science, 2010, roč. 6, č. 2, s. 1-9. ISSN 1553-7366.
Další formáty:   BibTeX LaTeX RIS
Základní údaje
Originální název Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism
Název česky Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism
Autoři WANG, Zhi (156 Čína), Christine WILHELMSSON (752 Švédsko), Pavel HYRŠL (203 Česká republika, garant), Torsten G. LOOF (752 Švédsko), Pavel DOBEŠ (203 Česká republika), Martina KLUPP (752 Švédsko), Olga LOSEVA (752 Švédsko), Matthias MÖRGELIN (752 Švédsko), Jennifer IKLÉ (752 Švédsko), Richard M. CRIPPS (752 Švédsko), Heiko HERWALD (752 Švédsko) a Ulrich THEOPOLD (752 Švédsko).
Vydání PLoS Pathogens, San Francisco, Public Library Science, 2010, 1553-7366.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Immunology
Stát vydavatele Spojené státy americké
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 9.079
Kód RIV RIV/00216224:14310/10:00043068
Organizační jednotka Přírodovědecká fakulta
UT WoS 000275295900015
Klíčová slova česky Drosophila; Immunity; Transglutaminase
Klíčová slova anglicky Drosophila; Immunity; Transglutaminase
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnil: Mgr. Pavel Dobeš, Ph.D., učo 150960. Změněno: 17. 10. 2010 09:56.
Anotace
Clotting systems are required in almost all animals to prevent loss of body fluids after injury. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using both a human and a natural insect pathogen we provide functional proof for an immune function for transglutaminase (TG). Drosophila larvae with reduced TG levels show increased mortality after septic injury. The same larvae are also more susceptible to a natural infection involving entomopathogenic nematodes and their symbiotic bacteria while neither phagocytosis, phenoloxidase or - as previously shown- the Toll or imd pathway contribute to immunity. These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.
Anotace česky
Clotting systems are required in almost all animals to prevent loss of body fluids after injury. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using both a human and a natural insect pathogen we provide functional proof for an immune function for transglutaminase (TG). Drosophila larvae with reduced TG levels show increased mortality after septic injury. The same larvae are also more susceptible to a natural infection involving entomopathogenic nematodes and their symbiotic bacteria while neither phagocytosis, phenoloxidase or - as previously shown- the Toll or imd pathway contribute to immunity. These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.
VytisknoutZobrazeno: 21. 8. 2019 17:56