Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism

WANG, Zhi; Christine WILHELMSSON; Pavel HYRŠL; Torsten G. LOOF; Pavel DOBEŠ; Martina KLUPP; Olga LOSEVA; Matthias MÖRGELIN; Jennifer IKLÉ; Richard M. CRIPPS; Heiko HERWALD a Ulrich THEOPOLD. Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism. PLoS Pathogens. San Francisco: Public Library Science, 2010, roč. 6, č. 2, s. 1-9. ISSN 1553-7366.

Základní údaje

Originální název

Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism

Název česky

Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism

Autoři

WANG, Zhi; Christine WILHELMSSON; Pavel HYRŠL; Torsten G. LOOF; Pavel DOBEŠ; Martina KLUPP; Olga LOSEVA; Matthias MÖRGELIN; Jennifer IKLÉ; Richard M. CRIPPS; Heiko HERWALD a Ulrich THEOPOLD

Vydání

PLoS Pathogens, San Francisco, Public Library Science, 2010, 1553-7366

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.079

Kód RIV

RIV/00216224:14310/10:00043068

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000275295900015

Klíčová slova česky

Drosophila; Immunity; Transglutaminase

Klíčová slova anglicky

Drosophila; Immunity; Transglutaminase

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Clotting systems are required in almost all animals to prevent loss of body fluids after injury. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using both a human and a natural insect pathogen we provide functional proof for an immune function for transglutaminase (TG). Drosophila larvae with reduced TG levels show increased mortality after septic injury. The same larvae are also more susceptible to a natural infection involving entomopathogenic nematodes and their symbiotic bacteria while neither phagocytosis, phenoloxidase or - as previously shown- the Toll or imd pathway contribute to immunity. These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.

Česky

Clotting systems are required in almost all animals to prevent loss of body fluids after injury. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using both a human and a natural insect pathogen we provide functional proof for an immune function for transglutaminase (TG). Drosophila larvae with reduced TG levels show increased mortality after septic injury. The same larvae are also more susceptible to a natural infection involving entomopathogenic nematodes and their symbiotic bacteria while neither phagocytosis, phenoloxidase or - as previously shown- the Toll or imd pathway contribute to immunity. These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.