| WANG, Zhi, Christine WILHELMSSON, Pavel HYRŠL, Torsten G. LOOF, Pavel DOBEŠ, Martina KLUPP, Olga LOSEVA, Matthias MÖRGELIN, Jennifer IKLÉ, Richard M. CRIPPS, Heiko HERWALD a Ulrich THEOPOLD. Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism. PLoS Pathogens. San Francisco: Public Library Science, 2010, roč. 6, č. 2, s. 1-9. ISSN 1553-7366. |
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@article{862714,
author = {Wang, Zhi and Wilhelmsson, Christine and Hyršl, Pavel and Loof, Torsten G. and Dobeš, Pavel and Klupp, Martina and Loseva, Olga and Mörgelin, Matthias and Iklé, Jennifer and Cripps, Richard M. and Herwald, Heiko and Theopold, Ulrich},
article_location = {San Francisco},
article_number = {2},
keywords = {Drosophila; Immunity; Transglutaminase},
language = {eng},
issn = {1553-7366},
journal = {PLoS Pathogens},
title = {Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism},
url = {http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000763},
volume = {6},
year = {2010}
}
TY - JOUR
ID - 862714
AU - Wang, Zhi - Wilhelmsson, Christine - Hyršl, Pavel - Loof, Torsten G. - Dobeš, Pavel - Klupp, Martina - Loseva, Olga - Mörgelin, Matthias - Iklé, Jennifer - Cripps, Richard M. - Herwald, Heiko - Theopold, Ulrich
PY - 2010
TI - Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism
JF - PLoS Pathogens
VL - 6
IS - 2
SP - 1-9
EP - 1-9
PB - Public Library Science
SN - 15537366
KW - Drosophila
KW - Immunity
KW - Transglutaminase
UR - http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000763
N2 - Clotting systems are required in almost all animals to prevent loss of body fluids after injury. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using both a human and a natural insect pathogen we provide functional proof for an immune function for transglutaminase (TG). Drosophila larvae with reduced TG levels show increased mortality after septic injury. The same larvae are also more susceptible to a natural infection involving entomopathogenic nematodes and their symbiotic bacteria while neither phagocytosis, phenoloxidase or - as previously shown- the Toll or imd pathway contribute to immunity. These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.
ER -
WANG, Zhi, Christine WILHELMSSON, Pavel HYRŠL, Torsten G. LOOF, Pavel DOBEŠ, Martina KLUPP, Olga LOSEVA, Matthias MÖRGELIN, Jennifer IKLÉ, Richard M. CRIPPS, Heiko HERWALD a Ulrich THEOPOLD. Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism. \textit{PLoS Pathogens}. San Francisco: Public Library Science, 2010, roč.~6, č.~2, s.~1-9. ISSN~1553-7366.
|
