Comparing recommended doses of angiotensin receptor blockers
and ACE inhibitors (CORD Study)

J 2009

Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study)

ŠPINAR, Jindřich; Jiří VÍTOVEC; Miroslav SOUČEK; Ladislav DUŠEK; Tomas PAVLIK et al.

Základní údaje

Originální název

Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study)

Autoři

ŠPINAR, Jindřich; Jiří VÍTOVEC; Miroslav SOUČEK; Ladislav DUŠEK a Tomas PAVLIK

Vydání

CARDIOVASCULAR THERAPY AND PREVENTION, 2009, 1728-8800

Další údaje

Jazyk

ruština

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Rusko

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

UT WoS

000267161400012

Klíčová slova anglicky

Arterial hypertension; isolated systolic hypertension; ramipril; losartan; metabolic parameters; cough

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 1. 2010 21:30, RNDr. Tomáš Pavlík, Ph.D.

Anotace

V originále

The CORD Study compared effectiveness and tolerability of losartan and ramipril in patients with arterial hypertension (AH). Material and methods. The study included two groups, A and B. In Group A (n=4016; mean age 62,6 +/- 11,6 years; 53, 1 % women), the patients with blood pressure (BP) < 160/100 mm Hg and ACE inhibitor therapy lasting for >3 months were switched from ACE inhibitors to losartan. At baseline and 1, 3, 6, and 12 months later, BP, heart rate, and biochemical parameters were measured; general blood assay and electrocardiography (ECG) were also performed. In group B (n=3813; mean age 60,5 +/- 12,2 years; 50,5% women), the patients with BP >= 140/90 mm Hg and no previous ACE inhibitor or angiotensin receptor blocker (ARB) therapy were randomly administered either losartan (50 mg/d; n=1887) or ramipril (5 mg/d; n= 1926). Results. Group A demonstrated a decrease in BP - from 147,4 +/- 14,8/87,7 +/- 9,3 to 139,7 +/- 11,8/83,0 +/- 9,3 mm Hg (p<0,001) after one month of the treatment, and to 133,7 +/- 11,3/79,1 +/- 7,06 mm Hg (p<0,001) after one year. Adverse effect prevalence did not increase. After one year, Group B demonstrated a reduction in BP levels - in losartan subgroup, from 156,5 +/- 13,1/93,4 +/- 8,8 to 134,55 +/- 11,3/80,16 +/- 6,6 mm Hg (p<0,001), and in ramipril subgrOLIP-from 155,9 +/- 13,1/93,0 +/- 8,9 to 134,1 +/- 11,2/81,5 +/- 6,8 mm Hg (p<0,001). No severe adverse effects were registered, but in ramipril subgroup, cough was 8 times more prevalent. Conclusion. ACE inhibitor substitution with losartan was safe and effective. Losartan and ramipril demonstrated equal anti hypertensive effectiveness and a tendency to improve metabolic parameters. Losartan therapy was better tolerated than ramipril.

Citovat

ŠPINAR, Jindřich; Jiří VÍTOVEC; Miroslav SOUČEK; Ladislav DUŠEK a Tomas PAVLIK. Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study). CARDIOVASCULAR THERAPY AND PREVENTION. 2009, roč. 8, č. 4, s. 63-70. ISSN 1728-8800.

@article{869331,
   author = {Špinar, Jindřich and Vítovec, Jiří and Souček, Miroslav and Dušek, Ladislav and Pavlik, Tomas},
   article_number = {4},
   keywords = {Arterial hypertension; isolated systolic hypertension; ramipril; losartan; metabolic parameters; cough},
   language = {rus},
   issn = {1728-8800},
   journal = {CARDIOVASCULAR THERAPY AND PREVENTION},
   title = {Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study)},
   volume = {8},
   year = {2009}
}

TY  - JOUR
ID  - 869331
AU  - Špinar, Jindřich - Vítovec, Jiří - Souček, Miroslav - Dušek, Ladislav - Pavlik, Tomas
PY  - 2009
TI  - Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study)
JF  - CARDIOVASCULAR THERAPY AND PREVENTION
VL  - 8
IS  - 4
SP  - 63-70
EP  - 63-70
SN  - 17288800
KW  - Arterial hypertension
KW  - isolated systolic hypertension
KW  - ramipril
KW  - losartan
KW  - metabolic parameters
KW  - cough
N2  - The CORD Study compared effectiveness and tolerability of losartan and ramipril in patients with arterial hypertension (AH). Material and methods. The study included two groups, A and B. In Group A (n=4016; mean age 62,6 +/- 11,6 years; 53, 1 % women), the patients with blood pressure (BP) < 160/100 mm Hg and ACE inhibitor therapy lasting for >3 months were switched from ACE inhibitors to losartan. At baseline and 1, 3, 6, and 12 months later, BP, heart rate, and biochemical parameters were measured; general blood assay and electrocardiography (ECG) were also performed. In group B (n=3813; mean age 60,5 +/- 12,2 years; 50,5% women), the patients with BP >= 140/90 mm Hg and no previous ACE inhibitor or angiotensin receptor blocker (ARB) therapy were randomly administered either losartan (50 mg/d; n=1887) or ramipril (5 mg/d; n= 1926). Results. Group A demonstrated a decrease in BP - from 147,4 +/- 14,8/87,7 +/- 9,3 to 139,7 +/- 11,8/83,0 +/- 9,3 mm Hg (p<0,001) after one month of the treatment, and to 133,7 +/- 11,3/79,1 +/- 7,06 mm Hg (p<0,001) after one year. Adverse effect prevalence did not increase. After one year, Group B demonstrated a reduction in BP levels - in losartan subgroup, from 156,5 +/- 13,1/93,4 +/- 8,8 to 134,55 +/- 11,3/80,16 +/- 6,6 mm Hg (p<0,001), and in ramipril subgrOLIP-from 155,9 +/- 13,1/93,0 +/- 8,9 to 134,1 +/- 11,2/81,5 +/- 6,8 mm Hg (p<0,001). No severe adverse effects were registered, but in ramipril subgroup, cough was 8 times more prevalent. Conclusion. ACE inhibitor substitution with losartan was safe and effective. Losartan and ramipril demonstrated equal anti hypertensive effectiveness and a tendency to improve metabolic parameters. Losartan therapy was better tolerated than ramipril.
ER  -

ŠPINAR, Jindřich; Jiří VÍTOVEC; Miroslav SOUČEK; Ladislav DUŠEK a Tomas PAVLIK. Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study). \textit{CARDIOVASCULAR THERAPY AND PREVENTION}. 2009, roč.~8, č.~4, s.~63-70. ISSN~1728-8800.

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