| NĚMEC, Pavel, Zuzana ZEMANOVÁ, Henrieta GREŠLIKOVÁ, Kyra MICHALOVÁ, Hana FILKOVÁ, Jana TAJTLOVÁ, Dana KRÁLOVÁ, Renata KUPSKÁ, Jan SMETANA, Marta KREJČÍ, Luděk POUR, Lenka ZAHRADOVÁ, Viera SANDECKÁ, Zdeněk ADAM, Tomáš BÜCHLER, Ivan ŠPIČKA, Evžen GREGORA, Petr KUGLÍK a Roman HÁJEK. Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy. Biology of Blood and Marrow Transplantation. USA: Carden Jennings Publishing, roč. 16, č. 4, s. 548-554. ISSN 1083-8791. 2010. |
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@article{870109,
author = {Němec, Pavel and Zemanová, Zuzana and Grešliková, Henrieta and Michalová, Kyra and Filková, Hana and Tajtlová, Jana and Králová, Dana and Kupská, Renata and Smetana, Jan and Krejčí, Marta and Pour, Luděk and Zahradová, Lenka and Sandecká, Viera and Adam, Zdeněk and Büchler, Tomáš and Špička, Ivan and Gregora, Evžen and Kuglík, Petr and Hájek, Roman},
article_location = {USA},
article_number = {4},
keywords = {Multiple myeloma; 1q21 Gain; Survival; Chromosomal aberrations; Fluorescein in situ hybridization},
language = {eng},
issn = {1083-8791},
journal = {Biology of Blood and Marrow Transplantation},
title = {Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy},
volume = {16},
year = {2010}
}
TY - JOUR
ID - 870109
AU - Němec, Pavel - Zemanová, Zuzana - Grešliková, Henrieta - Michalová, Kyra - Filková, Hana - Tajtlová, Jana - Králová, Dana - Kupská, Renata - Smetana, Jan - Krejčí, Marta - Pour, Luděk - Zahradová, Lenka - Sandecká, Viera - Adam, Zdeněk - Büchler, Tomáš - Špička, Ivan - Gregora, Evžen - Kuglík, Petr - Hájek, Roman
PY - 2010
TI - Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy
JF - Biology of Blood and Marrow Transplantation
VL - 16
IS - 4
SP - 548-554
EP - 548-554
PB - Carden Jennings Publishing
SN - 10838791
KW - Multiple myeloma
KW - 1q21 Gain
KW - Survival
KW - Chromosomal aberrations
KW - Fluorescein in situ hybridization
N2 - The prognostic significance of 1q21 gain, del(13)(q14), del(17)(p13), t(4;14)(p16.3;q32), and t(11;14)(q13;q32) detected by interphase fluorescein in situ hybridization (FISH) was studied in a cohort of 91 patients with newly diagnosed multiple myeloma (MM). 1q21 gain was detected in 37 of 91 patients (40.7%). In comparison with patients lacking 1q21 gain, patients with 1q21 gain had significantly shorter progression-free survival (PFS) (14.9 versus 27.4 months; P = .044) and worse 4-year overall survival (OS) (40.1% versus 76.2% of patients; P = <.001). PFS or OS were not influenced by the presence or absence of the other studied chromosomal abnormalities. Although the occurrence of 1q21 gain correlated with deletion of 13q14, the presence of 1q21 gain can be considered an independent prognostic factor, as no impact of del(13)(q14) as an isolated chromosomal abnormality on either PFS or OS has been observed. We conclude that 1q21 gain defines a prognostically unfavorable group of MM patients.
ER -
NĚMEC, Pavel, Zuzana ZEMANOVÁ, Henrieta GREŠLIKOVÁ, Kyra MICHALOVÁ, Hana FILKOVÁ, Jana TAJTLOVÁ, Dana KRÁLOVÁ, Renata KUPSKÁ, Jan SMETANA, Marta KREJČÍ, Luděk POUR, Lenka ZAHRADOVÁ, Viera SANDECKÁ, Zdeněk ADAM, Tomáš BÜCHLER, Ivan ŠPIČKA, Evžen GREGORA, Petr KUGLÍK a Roman HÁJEK. Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy. \textit{Biology of Blood and Marrow Transplantation}. USA: Carden Jennings Publishing, roč.~16, č.~4, s.~548-554. ISSN~1083-8791. 2010.
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