Combined treatment of achalasia - botulinum toxin injection
followed by pneumatic dilatation: long-term results

J 2010

Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results

KROUPA, Radek, Aleš HEP, Jiří DOLINA, Vlastimil VÁLEK, Zuzana MATYÁŠOVÁ et. al.

Základní údaje

Originální název

Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results

Autoři

KROUPA, Radek (203 Česká republika, garant, domácí), Aleš HEP (203 Česká republika, domácí), Jiří DOLINA (203 Česká republika, domácí), Vlastimil VÁLEK (203 Česká republika, domácí), Zuzana MATYÁŠOVÁ (203 Česká republika), Jitka PROKEŠOVÁ (203 Česká republika, domácí), Jaroslav SEDMÍK (203 Česká republika, domácí) a Ivo NOVOTNÝ (203 Česká republika, domácí)

Vydání

Diseases of the Esophagus, Wiley blackwell, 2010, 1120-8694

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.536

Kód RIV

RIV/00216224:14110/10:00043346

Organizační jednotka

Lékařská fakulta

UT WoS

000274622100003

Klíčová slova anglicky

achalasia - botulinum toxin- pneumatic dilatatation- therapy

Příznaky

Mezinárodní význam

Změněno: 10. 1. 2011 13:54, doc. MUDr. Radek Kroupa, Ph.D.

Anotace

V originále

Injection of botulinum toxin (BT) and pneumatic dilatation are available methods in nonsurgical treatment of achalasia. Authors anticipate beneficial effect of prior BT injection on the success of pneumatic dilatation and duration of its effect. There are no long-term data available to assess efficacy of combined treatment.Result of prospective study on 51 consecutive patients treated by comination method are presented. The cumulative 5 years remission rate in combined treated patients 69% was higher than in controls 50%; however it, was not statistically significant (P = 0.07). Eight patients (17%) with relapse of dysphagia were referred to laparoscopic Heller myotomy with no surgical complication.Initial injection of BT followed by PD seems to be effective for long-term results with fewer complications. But the combined therapy is not significantly superior to PD alone.

Návaznosti

2B06060, projekt VaV

Název: Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu (Akronym: NPVII11002)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu

Citovat

KROUPA, Radek, Aleš HEP, Jiří DOLINA, Vlastimil VÁLEK, Zuzana MATYÁŠOVÁ, Jitka PROKEŠOVÁ, Jaroslav SEDMÍK a Ivo NOVOTNÝ. Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results. Diseases of the Esophagus. Wiley blackwell, 2010, roč. 23, č. 2, s. 100-105. ISSN 1120-8694.

@article{871629,
   author = {Kroupa, Radek and Hep, Aleš and Dolina, Jiří and Válek, Vlastimil and Matyášová, Zuzana and Prokešová, Jitka and Sedmík, Jaroslav and Novotný, Ivo},
   article_number = {2},
   keywords = {achalasia - botulinum toxin- pneumatic dilatatation- therapy},
   language = {eng},
   issn = {1120-8694},
   journal = {Diseases of the Esophagus},
   title = {Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results},
   volume = {23},
   year = {2010}
}

TY  - JOUR
ID  - 871629
AU  - Kroupa, Radek - Hep, Aleš - Dolina, Jiří - Válek, Vlastimil - Matyášová, Zuzana - Prokešová, Jitka - Sedmík, Jaroslav - Novotný, Ivo
PY  - 2010
TI  - Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results
JF  - Diseases of the Esophagus
VL  - 23
IS  - 2
SP  - 100-105
EP  - 100-105
PB  - Wiley blackwell
SN  - 11208694
KW  - achalasia - botulinum toxin- pneumatic dilatatation- therapy
N2  - Injection of botulinum toxin (BT) and pneumatic dilatation are available methods in nonsurgical treatment of achalasia. Authors anticipate beneficial effect of prior BT injection on the success of pneumatic dilatation and duration of its effect. There are no long-term data available to assess efficacy of combined treatment.Result of prospective study on 51 consecutive patients treated by comination method are presented. The cumulative 5 years remission rate in combined treated patients 69% was higher than in controls 50%; however it, was not statistically significant (P = 0.07). Eight patients (17%) with relapse of dysphagia were referred to laparoscopic Heller myotomy with no surgical complication.Initial injection of BT followed by PD seems to be effective for long-term results with fewer complications. But the combined therapy is not significantly superior to PD alone.
ER  -

KROUPA, Radek, Aleš HEP, Jiří DOLINA, Vlastimil VÁLEK, Zuzana MATYÁŠOVÁ, Jitka PROKEŠOVÁ, Jaroslav SEDMÍK a Ivo NOVOTNÝ. Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results. \textit{Diseases of the Esophagus}. Wiley blackwell, 2010, roč.~23, č.~2, s.~100-105. ISSN~1120-8694.

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