Specific toxic effects of complex extracts from gas phase and
six fractions of air particulate matter from localities with
different pollution sources

a 2009

Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources

NOVÁK, Jiří, Jiří SMUTNÝ, Pavel ČUPR, Jana KLÁNOVÁ, Giesy JOHN et. al.

Základní údaje

Originální název

Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources

Název česky

Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources

Autoři

NOVÁK, Jiří, Jiří SMUTNÝ, Pavel ČUPR, Jana KLÁNOVÁ, Giesy JOHN, Klára HILSCHEROVÁ a Michal BITTNER

Vydání

SETAC Europe 19th Annual Meeting Goteborg, 2009

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10511 Environmental sciences

Stát vydavatele

Švédsko

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

Znečištění ovzduší; specifické aktivity; prachové částice

Klíčová slova anglicky

Air pollution; specific activity; particle matter

Změněno: 8. 3. 2010 10:23, Mgr. Jiří Novák, Ph.D.

Anotace

ORIG CZ

V originále

Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.

Česky

viz anglický

Návaznosti

SP/1A3/29/07, projekt VaV

Název: Komplexní charakterizace prachových frakci ve volném ovzduší (AirToxPM) (Akronym: AirToxPM)

Investor: Ministerstvo životního prostředí ČR, Komplexní charakterizace prachových frakcí ve volném ovzduší

2B08036, projekt VaV

Název: Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů (Akronym: ENVISCREEN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů

Citovat

NOVÁK, Jiří, Jiří SMUTNÝ, Pavel ČUPR, Jana KLÁNOVÁ, Giesy JOHN, Klára HILSCHEROVÁ a Michal BITTNER. Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources. In SETAC Europe 19th Annual Meeting Goteborg. 2009.

@proceedings{872287,
   author = {Novák, Jiří and Smutný, Jiří and Čupr, Pavel and Klánová, Jana and John, Giesy and Hilscherová, Klára and Bittner, Michal},
   booktitle = {SETAC Europe 19th Annual Meeting Goteborg},
   keywords = {Air pollution; specific activity; particle matter},
   language = {eng},
   title = {Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources},
   year = {2009}
}

TY  - CONF
ID  - 872287
AU  - Novák, Jiří - Smutný, Jiří - Čupr, Pavel - Klánová, Jana - John, Giesy - Hilscherová, Klára - Bittner, Michal
PY  - 2009
TI  - Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources
KW  - Air pollution
KW  - specific activity
KW  - particle matter
N2  - Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.
ER  -

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