a 2009

Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources

NOVÁK, Jiří, Jiří SMUTNÝ, Pavel ČUPR, Jana KLÁNOVÁ, Giesy JOHN et. al.

Basic information

Original name

Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources

Name in Czech

Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources

Authors

Edition

SETAC Europe 19th Annual Meeting Goteborg, 2009

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10511 Environmental sciences

Country of publisher

Sweden

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords (in Czech)

Znečištění ovzduší; specifické aktivity; prachové částice

Keywords in English

Air pollution; specific activity; particle matter
Změněno: 8/3/2010 10:23, Mgr. Jiří Novák, Ph.D.

Abstract

ORIG CZ

V originále

Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.

In Czech

viz anglický

Links

SP/1A3/29/07, research and development project
Name: Komplexní charakterizace prachových frakci ve volném ovzduší (AirToxPM) (Acronym: AirToxPM)
Investor: Ministry of the Environment of the CR, Complex characterisation of the particulate fractions in ambient air
2B08036, research and development project
Name: Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů (Acronym: ENVISCREEN)
Investor: Ministry of Education, Youth and Sports of the CR, New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.