2009
Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources
LANDLOVÁ, Linda; Jiří NOVÁK; Pavel ČUPR; Jana KLÁNOVÁ; Giesy JOHN et al.Základní údaje
Originální název
Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources
Název česky
Specifické toxické efekty komplexních extraktů vzorků plynné frakce vzduchu a šesti velikostních frakcí vzdušného aerosolu z lokalit s různými zdroji znečištění
Název anglicky
Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources
Autoři
Vydání
Praha, Nucleation and Atmospheric Aerosols, od s. 960-964, 4 s. 2009
Nakladatel
Institute of Chemical Process Fundamentals ASCR
Další údaje
Typ výsledku
Stať ve sborníku
Obor
10511 Environmental sciences
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ne
Organizační jednotka
Přírodovědecká fakulta
ISBN
978-80-02-12161-9
Klíčová slova anglicky
air particulate matter, size fractions, dioxin-like, estrogenicity, antiandrogenicity
Změněno: 22. 2. 2010 10:42, Mgr. Jiří Novák, Ph.D.
V originále
Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.
Česky
Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.
Návaznosti
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